Enzymes as Parts in Need of Replacement - and How to Extend Their Working Life

Trends in Plant Science
Nathan D TivendaleA Harvey Millar

Abstract

Enzymes catalyze reactions in vivo at different rates and each enzyme molecule has a lifetime limit before it is degraded and replaced to enable catalysis to continue. Considering these rates together as a unitless ratio of catalytic cycles until replacement (CCR) provides a new quantitative tool to assess the replacement schedule of and energy investment into enzymes as they relate to function. Here, we outline the challenges of determining CCRs and new approaches to overcome them and then assess the CCRs of selected enzymes in bacteria and plants to reveal a range of seven orders of magnitude for this ratio. Modifying CCRs in plants holds promise to lower cellular costs, to tailor enzymes for particular environments, and to breed enzyme improvements for crop productivity.

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Citations

May 23, 2020·The Biochemical Journal·Jaya JoshiAndrew D Hanson
Mar 24, 2021·Proceedings of the National Academy of Sciences of the United States of America·Andrew D HansonA Harvey Millar
Apr 3, 2021·Photosynthesis Research·Juan Alejandro PerdomoElizabete Carmo-Silva
Jun 22, 2021·The Plant Journal : for Cell and Molecular Biology·Nathan D TivendaleA Harvey Millar
Aug 20, 2021·The Biochemical Journal·Jaya JoshiAndrew D Hanson

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