Enzymes in the cerebrospinal fluid in diagnosis of brain death.

Resuscitation
C VoisinC Chopin

Abstract

The increase of enzymes in the cerebrospinal fluid is shown to indicate an adverse prognosis, with the implication of irreversibility. The massive increase of glutamate-oxaloacetate transaminase and lactate dehydrogenase and the appearance of alkaline phosphatases in a sample of cerebrospinal fluid in which the cytology is normal constitute an easy and reliable test for brain death. The increase in lactate dehydrogenase fraction V and lysozyme in cerebrospinal fluid supports the macrophagic origin of these enzymes.

Citations

Aug 17, 1978·The New England Journal of Medicine·P M Black
Nov 1, 1986·Journal of Neurosurgery·L RabowJ P Muizelaar
Aug 1, 1983·Resuscitation·B A Blair-St Giles, H Hillman
Aug 10, 2000·Protein Science : a Publication of the Protein Society·A F MonzingoJ D Robertus
May 31, 2012·Journal of Structural and Functional Genomics·David M Lawson, Clare E M Stevenson

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