Enzymes of carbohydrate metabolism as potential drug targets

International Journal for Parasitology
F R Opperdoes, Paul A M Michels

Abstract

The potential for chemotherapeutic exploitation of carbohydrate metabolism in the Trypanosomatidae is reviewed. This review is based largely on discussions held at a meeting of the COST B9 Action, entitled 'Bioenergetics of Protozoan Parasites'. The major questions posed were: which enzymes are the best to target; what further information is required to allow their use for rational drug development; what compounds would constitute the best inhibitors and which of the enzymes of the pentose-phosphate pathway are present inside the glycosomes, as well? Only partial answers could be obtained in many cases, but the interactive discussion between the multidisciplinary group of participants, comprising chemists, biochemists and molecular biologists, provided thought-provoking ideas and will help direct future research.

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Citations

Dec 26, 2009·Archives of Microbiology·Matías D Asención DiezAlberto A Iglesias
Oct 25, 2006·Parasitology Research·Miguel A PabónJuan L Concepción
Nov 11, 2008·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Myoung-Ki HongLin-Woo Kang
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Jul 17, 2008·Journal of Biomedicine & Biotechnology·Rafael Moreno-SánchezViridiana Olín-Sandoval
Aug 15, 2012·International Journal of Medical Microbiology : IJMM·Leopold Flohé
Dec 7, 2011·International Journal for Parasitology·Melisa Gualdrón-LópezPaul A M Michels
Sep 24, 2011·Research in Veterinary Science·Nathan HabilaEmmanuel Haruna
Mar 27, 2007·Experimental Parasitology·Wilfredo QuiñonesJuan Luis Concepción
Mar 22, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cecilia OrtizMarcelo A Comini
Mar 8, 2012·The FEBS Journal·Viridiana Olin-SandovalEmma Saavedra
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May 18, 2016·Biochemistry Research International·Arpita Singh, Debjani Mandal
Nov 13, 2004·FEMS Microbiology Reviews·Juliette MoyersoenPaul A M Michels
Feb 3, 2009·Biochimica Et Biophysica Acta·Emilie VerplaetsePaul A M Michels
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Sep 15, 2015·PloS One·Abhishek SubramanianRam Rup Sarkar
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Oct 23, 2018·Frontiers in Cellular and Infection Microbiology·Joseph D LykinsHuân M Ngô
Jun 16, 2005·The Journal of Biological Chemistry·Marie-Astrid AlbertPaul A M Michels

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