PMID: 6108352Dec 1, 1980Paper

Enzymes related to monoamine transmitter metabolism in brain microvessels

Journal of Neurochemistry
J E HardeboE Rosengren

Abstract

The activities of tyrosine hydroxylase, aromatic L-aminoacid decarboxylase, monoamine oxidase, and catechol-O-methyltransferase were measured in microvessel (capillaries and venules), parenchymal arterioles, and pial vessels from rat brains, and the decarboxylase activity was compared in brain microvessels from rabbit, cat, dog, pig, cow, baboon, and man. Cranial sympathectomy was performed to estimate the neuronal contribution to the enzyme activities. All vascular regions had substantial activities of the various enzymes studied. The activity of aromatic L-aminoacid decarboxylase in cerebral microvessels was high in rat, dog, pig, cow, and man; intermediate in rabbit and cat; and low in baboon. In addition to this enzyme, cerebral microvessels also contained tyrosine hydroxylase and monoamine oxidase. Aromatic aminoacid decarboxylase and monoamine oxidase serve an enzymatic barrier function at the microvascular level, whereas the main function of tyrosine hydroxylase is probably to synthesize monoamines within nerve terminals that remain in close association with microvessels under the conditions used for preparation of the microvascular fraction. In larger intracerebral and pial vessels monoamine oxidase was present both in ...Continue Reading

References

Oct 1, 1977·The Journal of Physiology·M A Harper, E T MacKenzie
Jan 1, 1977·Journal of Neurochemistry·W M Pardridge, W H Oldendorf
Mar 1, 1977·Acta Physiologica Scandinavica·J E HardeboE Rosengren
Aug 1, 1976·The American Journal of Physiology·E T MacKenzieA M Harper
Feb 1, 1975·The American Journal of Physiology·L A Wade, R Katzman
Oct 1, 1975·The American Journal of Anatomy·M L Rennels, E Nelson
Dec 1, 1971·The American Journal of Physiology·W H Oldendorf
Jul 1, 1967·The Journal of Cell Biology·T S Reese, M J Karnovsky
Mar 1, 1980·Acta Physiologica Scandinavica·M LindvallC Owman
Mar 1, 1980·Acta Physiologica Scandinavica·J E Hardebo, C Owman
Jan 1, 1963·Acta Pharmacologica Et Toxicologica·A BERTLERE ROSENGREN

❮ Previous
Next ❯

Citations

Sep 9, 2004·Journal of Physiology and Biochemistry·A L López de PabloE J Marco
Jan 1, 1986·Neuroscience and Biobehavioral Reviews·G C Palmer
Jan 1, 1964·Acta Physiologica Scandinavica. Supplementum·A BERTLERC OWMAN
Aug 10, 2000·Journal of Clinical Pharmacology·R DursoT R Browne
Jun 30, 2000·Microvascular Research·F HernándezR E Catalán
Jul 1, 1984·Neurochemical Research·J Veselý, M Cernoch
Jan 1, 1991·Drug Metabolism Reviews·F J Leinweber
May 1, 1995·Blood Pressure·K Jandeleit-DahmC I Johnston
Aug 8, 2009·Journal of Neurochemistry·Paul M CarveyAngela J Monahan
Aug 1, 1989·Journal of Neurochemistry·G K Scriba, R T Borchardt
Jun 1, 1985·Journal of Neurochemistry·P GrammasJ Wiener
Jun 1, 1996·Neuroscience Research·R E CatalánF Hernández
Sep 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J J Grome, A M Harper
Sep 1, 1984·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R SercombeJ Seylaz
Dec 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F LasbennesJ Seylaz
Jan 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H KuwabaraA Gjedde
Jan 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J Y ChangC Owman
Jun 1, 1986·Journal of Neurochemistry·A Baranczyk-KuzmaR T Borchardt
Mar 18, 1999·Cellular and Molecular Neurobiology·T NagashimaN Tamaki
May 1, 1985·Cephalalgia : an International Journal of Headache·A Agnoli, M De Marinis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.