PMID: 6416908Nov 1, 1983

Enzymic inactivation of hypothalamic regulatory hormones

Molecular and Cellular Endocrinology
E C Griffiths, J R McDermott

Abstract

The considerable expansion in studies on the enzymic inactivation of thyrotrophin-releasing hormone, luteinizing hormone-releasing hormone and somatostatin (growth hormone release-inhibiting hormone) has necessitated a re-evaluation of the peptidase enzymes responsible. Through the use of new methods such as high-performance liquid chromatography and the development of artificial enzyme substrates, it has been possible to clarify the mechanisms of enzyme cleavage of these hypothalamic regulatory hormones and to attempt purification of the peptidases. This has brought about a renewed interest in the physiological significance of the enzymes, as well as their role in biotransformation of the hypothalamic hormones. From such studies, the information gained may be used in the design of agonist and antagonist analogues, as well as providing details of the mechanisms of action of such analogues through their increased stability to enzymic degradation. The characterization of corticotrophin-releasing factor and growth hormone-releasing factor will provide a new field for the application of peptidase inactivation to analogue design. Similarly, future examination of the peptidases inactivating the hypothalamic hormones in certain clinic...Continue Reading

References

Jan 1, 1976·Hormone Research·E C Griffiths
Jul 1, 1979·The Journal of Clinical Endocrinology and Metabolism·C H EmersonB L Currie
Apr 1, 1979·Molecular and Cellular Endocrinology·E C Griffiths, J A Kelly
Jan 1, 1979·Endocrinology·V SchusdziarraR H Unger
Aug 1, 1979·Journal of Neurochemistry·M OrlowskiS Wilk
Feb 1, 1979·Journal of Neurochemistry·T N AkopyanA A Galoyan
Dec 17, 1974·British Dental Journal·D H Goose
Oct 1, 1973·The Journal of Clinical Endocrinology and Metabolism·T W ReddingA V Schally
Apr 29, 1980·Biochemical and Biophysical Research Communications·H H Zingg, Y C Patel
Oct 1, 1980·Metabolism: Clinical and Experimental·J W LeitnerK E Sussman
Feb 1, 1981·The Journal of Clinical Investigation·H Sacks, L C Terry
May 29, 1981·Biochemical and Biophysical Research Communications·B HorsthemkeK Bauer
Aug 1, 1981·European Journal of Biochemistry·K BauerH Kleinkauf
Nov 1, 1981·The Journal of Clinical Investigation·K PolonskyJ Dhorajiwala
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·P BrazeauR Guillemin
Dec 15, 1982·Biochemical and Biophysical Research Communications·M MoriJ F Wilber
Jan 1, 1980·Neuroscience·I W ChubbG H White
Jun 1, 1982·The Journal of Clinical Endocrinology and Metabolism·J L BarronD Searle
Nov 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·E HazumP M Conn
Jul 9, 1981·The New England Journal of Medicine·A C King, P Cuatrecasas
Apr 1, 1982·Behavioural Brain Research·B SiegfriedC Castellano
Nov 1, 1982·The Journal of Clinical Endocrinology and Metabolism·H M SchulteD L Loriaux
Feb 1, 1983·The Journal of Clinical Endocrinology and Metabolism·Y TakaharaA Peterkofsky
May 1, 1983·British Journal of Pharmacology·G BoschiS Wrigglesworth
Jan 1, 1980·The Journal of Clinical Endocrinology and Metabolism·S Aratan-Spire, P Czernichow
Apr 1, 1980·Molecular and Cellular Endocrinology·E C GriffithsT J Visser
Nov 25, 1980·Biochemistry·P C AndrewsJ E Dixon
Mar 15, 1981·Biochemical Pharmacology·D Brewster, K Waltham
Jan 1, 1981·Peptides·M F PachecoW S Griffin
Feb 1, 1982·General and Comparative Endocrinology·Y Grimm-Jørgensen, M J Borkowski
Aug 1, 1982·General and Comparative Endocrinology·E C GriffithsA I Smith
Feb 1, 1980·Neuroscience Letters·G BoschiR Rips
May 14, 1980·Biochemical and Biophysical Research Communications·W L Taylor, J E Dixon
Jun 1, 1980·Analytical Biochemistry·W L TaylorJ E Dixon
Oct 31, 1980·Biochemical and Biophysical Research Communications·P LeblancC Kordon
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R A MumfordM Zimmerman
Dec 31, 1981·Biochemical and Biophysical Research Communications·B Horsthemke, K Bauer
Nov 4, 1982·Brain Research·J J JacobsJ F Wilber

Citations

Jan 1, 1988·Pharmacology & Therapeutics·S P Robinson, V C Jordan
Mar 1, 1985·Regulatory Peptides·E C GriffithsW Klootwijk
Jun 1, 1986·Molecular and Cellular Endocrinology·M P HedgerD M de Kretser
Apr 1, 1986·Molecular and Cellular Endocrinology·T A Bramley, G S Menzies
Jun 6, 2000·Advanced Drug Delivery Reviews·M G Anderson, J D Miller
Jan 1, 1991·Progress in Growth Factor Research·A QayumJ Waxman
Jan 20, 1991·The New England Journal of Medicine·P M Conn, W F Crowley
Jan 1, 1989·Annals of the New York Academy of Sciences·E C GriffithsB Robson
Aug 1, 1987·Pain·V Reny-Palasse, R Rips
Jun 1, 1992·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·F MiróA Pellicer
Sep 1, 1994·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·H A Van Leusden
Aug 1, 1987·International Journal of Peptide and Protein Research·D J WardB Robson

Related Concepts

Aminopeptidase
Corticotropin-Releasing Hormone
Hypothalamic Hormones
Gonadorelin Hydrochloride
Peptide Hydrolases
Human Pancreatic Growth Hormone-Releasing Factor
Proterelin Tartrate Hydrate

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.