PMID: 9438647Jan 23, 1998Paper

Eosinophil cationic protein in Henoch-Schönlein purpura and in IgA nephropathy

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
M K NamgoongJ S Kim

Abstract

In order to identify the relationship between eosinophil activation in Henoch-Schönlein purpura (HSP) and IgA nephropathy, serum eosinophil cationic protein (ECP) was analyzed in both conditions. The soluble interleukin-2 receptor (sIL-2R) was also analyzed. The levels of ECP were significantly higher in HSP patients (mean 9.7 +/- 1.8 microg/l) than in a control group (mean 4.6 +/- 0.7 microg/l). When the HSP patients were classified into two groups, one with normal urine and one with abnormal urine, the latter showed higher levels of ECP than the former. Levels of ECP were not significantly higher in IgA nephropathy patients than in a control group. The sIL-2R levels were elevated in the serum of HSP and IgA nephropathy patients compared with controls. In conclusion, eosinophil activation may be involved in the pathogenesis of HSP but not in IgA nephropathy.

Citations

Feb 9, 2006·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Jianhua ZhouYujiu Kuang
Mar 28, 2007·Rheumatology International·Fulya TahanRuhan Dusunsel
Jun 16, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Keith K LauRobert J Wyatt
Jul 5, 2001·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·G Rostoker
Jan 28, 2014·World Journal of Pediatrics : WJP·Castellazzi Massimo LucaEmilio F Fossali
Jul 30, 2014·Nature Reviews. Nephrology·Jean-Claude Davin, Rosanna Coppo
Jan 16, 2013·Journal of Crohn's & Colitis·Se Jin Park, Jae Il Shin
Jun 23, 2011·Clinical and Experimental Nephrology·Yukihiko Kawasaki
Sep 30, 2005·Pediatrics International : Official Journal of the Japan Pediatric Society·Yukihiko KawasakiHitoshi Suzuki
Jan 6, 2015·World Journal of Pediatrics : WJP·Jun-Yi Chen, Jian-Hua Mao
Oct 28, 2018·Zeitschrift für Rheumatologie·C KroegelT Neumann
Aug 25, 2018·Der Internist·C KroegelT Neumann
May 25, 2004·Seminars in Nephrology·Noel M Delos Santos, Robert J Wyatt
Oct 18, 2005·La Presse médicale·P GuilpainL Mouthon

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