Eosinophil recruiting chemokines are down-regulated in peripheral blood mononuclear cells of allergic patients treated with deflazacort or desloratadine

International Journal of Immunopathology and Pharmacology
M B Di SciascioM. Di Gioacchino

Abstract

Chemokines are cytokines with chemotactic properties on leukocyte subsets whose modulation plays a key role in allergic inflammatory processes. To better understand the possible anti-inflammatory effects of histamine-1 receptor antagonists in allergic asthma, we studied the mRNA expression of a set of chemokines known to be involved in the eosinophils-basophils activation as well as recruitment and T-cell signaling events, before and after corticosteroid or antihistamine treatment in PBMCs from allergic-asthmatic patients ex vivo. Twelve patients were enrolled, all of whom were allergic to Parietaria judaica and suffering for mild persistent asthma: six were treated with desloratadine (10 mg/day), and six with deflazacort (12 mg/day). Before and after the treatment, PBMC samples were collected from each patient and analyzed for the expression of encoding mRNAs for several chemokines, I-309 (CCL1), MCP-1 (CCL2), MIP1-alpha (CCL3), MIP1-beta (CCL4), RANTES (CCL5), IL-8 (CXCL8), IP-10 (CXCL10), Lymphotactin (XCL1). Clinical and functional improvements were seen after 3 weeks of therapy; this was associated with a reduced expression in the mRNA levels for the chemokines RANTES, MIP1-alpha and MIP1-beta with either the corticosteroi...Continue Reading

References

Dec 5, 1997·The European Respiratory Journal·E Van GanseW Vincken
Apr 16, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C AlbanesiG Girolomoni
Nov 15, 2001·The Journal of Allergy and Clinical Immunology·J BousquetUNKNOWN World Health Organization
Dec 14, 2001·The Journal of Allergy and Clinical Immunology·J O Warner, UNKNOWN ETAC Study Group. Early Treatment of the Atopic Child
Feb 20, 2003·International Journal of Immunopathology and Pharmacology·G. BrunoS. Bracchitta
Feb 21, 2003·International Journal of Immunopathology and Pharmacology·M. Di GioacchinoT. C. Theoharides
Jun 12, 2003·The European Respiratory Journal·C BonnansI Vachier
Jul 10, 2003·Chemical Immunology·P J Barnes
Dec 4, 2003·International Archives of Allergy and Immunology·Duraisamy KempurajTheoharis C Theoharides
Jun 23, 2004·British Journal of Clinical Pharmacology·Daniel K C LeeBrian J Lipworth
Oct 6, 2004·International Journal of Immunopathology and Pharmacology·S FrydasM L Castellani
Oct 5, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Tom C FardonBrian J Lipworth

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Basophils

Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.