PMID: 8943897Dec 1, 1996Paper

Eosinophilia and granulocytic dysplasia terminating in acute myeloid leukaemia after 24 years

British Journal of Haematology
J K DoorduijnB Löwenberg

Abstract

Eosinophilia of variable duration, and subsequent progression to granulocytic sarcoma and acute myeloid leukaemia, has been infrequently reported in the literature. We report a patient with eosinophilia and normal cytogenetics who, after 24 years, showed transformation to a granulocytic sarcoma of the brain. Haematological counts were normal but the marrow revealed the cytogenetic abnormality trisomy 8 in 25% of mitoses. Subsequently an AML-M2 developed, showing a complex karyotype including the trisomy 8 in all metaphases. FISH analysis combined with cytological examination identified the trisomy 8 in blasts, eosinophils and dysplastic granulocytes only. Thus progressive leukaemic transformation selectively involved the myeloid compartment.

Citations

Oct 8, 1999·The New England Journal of Medicine·B J Bain
Apr 16, 2003·British Journal of Haematology·Finella Brito-Babapulle
Feb 27, 2009·British Journal of Haematology·Gerald J Gleich, Kristin M Leiferman
Nov 25, 1997·Blood Reviews·F Brito-Babapulle
Nov 11, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dana VédyOlivier Spertini
Nov 1, 2005·Expert Review of Clinical Immunology·Miguel L Stein, Marc E Rothenberg
Jan 25, 2003·Journal of Pediatric Hematology/oncology·Sameer BakhshiYaddanapudi Ravindranath

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