Eosinophilia, granuloma formation and migratory behaviour of larvae in the congenitally athymic mouse infected with Toxocara canis

Parasite Immunology
K Sugane, T Oshima

Abstract

Peripheral blood eosinophilia, histology of skeletal muscle and brain, and larval recovery were compared between congenitally athymic nude mice (nu/nu) and thymus-bearing heterozygous littermates (nu/+) for 6 weeks following oral infection with Toxocara canis eggs. By comparing patterns of peripheral blood eosinophil levels in nu/+ and nu/nu, two types of eosinophilias, one T cell dependent and the other independent, were observed. Eosinophil infiltration and granuloma formation around larvae in the skeletal muscle were weaker in degree in nu/nu than nu/+. The total number of larvae in nu/+ decreased from 2 to 6 weeks after infection. This decrease was directly related to a decrease in larval number in skeletal muscle, not in brain or other tissues. In contrast, no significant decrease of the total number of larvae was observed in nu/nu. The results indicate that eosinophilia, granuloma formation and larval recovery are closely related to cell-mediated immune mechanisms in T. canis-infected mice.

References

Mar 1, 1977·The Journal of Experimental Medicine·D I GroveK S Warren
Sep 1, 1977·The American Journal of Tropical Medicine and Hygiene·J E Byram, F von Lichtenberg
Jan 1, 1978·The Journal of Experimental Medicine·F J Ramalho-PintoS R Smithers
Sep 11, 1975·The Journal of Experimental Medicine·A A MahmoudR C Graham
Apr 1, 1972·Experimental Parasitology·B Machnicka
Jun 1, 1970·The Journal of Experimental Medicine·A Basten, P B Beeson
Jul 17, 1971·British Medical Journal·R S WallsA J Davies
Oct 1, 1981·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·P LangerK Gschwendtová
Nov 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·M GEORGE, J H VAUGHAN
Feb 9, 1946·Lancet·G DISCOMBE

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Citations

Jan 1, 1992·Veterinary Research Communications·B J McEwen
Feb 1, 1987·International Journal for Parasitology·T Oshima, M Kliks
Aug 1, 1985·Veterinary Immunology and Immunopathology·J E Concepcion, O O Barriga
Jun 1, 1983·Journal of Helminthology·K Sugane, T Oshima
Jun 1, 1987·Journal of Helminthology·K Sugane, T Matsuura
Mar 1, 1988·Journal of Helminthology·K Sugane
Jun 9, 2007·International Journal for Parasitology·Michelle L KnottLindsay A Dent
Sep 30, 2010·PLoS Neglected Tropical Diseases·Nicolas SalemJames P Basilion
Nov 21, 2007·Revista Do Instituto De Medicina Tropical De São Paulo·Josef Finsterer, Herbert Auer
Feb 16, 2018·Frontiers in Immunology·Joice Margareth de Almeida RodolphoFernanda de Freitas Anibal
Jan 8, 2000·The Journal of Biological Chemistry·M OwhashiN Hayai
Jun 1, 1985·Infection and Immunity·S G KayesR B Grieve

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