Eosinophilia, parasite burden and lung damage in Toxocara canis infection in C57Bl/6 mice genetically deficient in IL-5

Immunology
M TakamotoK I Matthaei

Abstract

C57Bl/6 mice genetically deficient in interleukin (IL)-5 (IL-5-/-) and mice with the normal IL-5 gene (IL-5+/+) were infected with embryonated eggs of Toxocara canis. IL-5+/+ mice developed a marked eosinophilia in their peripheral bloods and bone marrows after infection. In contrast, the number of eosinophils at these sites actually decreased during the acute phase of infection in IL-5-/- mice. A smaller number of eosinophils infiltrated the lung, liver, heart and skeletal muscle of infected IL-5-/- mice than those of infected IL-5+/+ mice. Eosinophils were not produced in cultures of bone marrow cells from either IL-5+/+ or IL-5-/- mice which were stimulated with excretory secretory antigen of T. canis larvae. The capacity of cells from the bone marrow to differentiate into eosinophils when stimulated in vitro with recombinant murine IL-5 was the same whether the cells were from IL-5+/+ or IL-5-/- mice. Taken together, these results show that an IL-5-like molecule is not produced by the T. canis larvae and that IL-5 produced by host cells is solely responsible for the eosinophilia in mice infected with this nematode. The number and location of T. canis larvae were not altered in the absence of IL-5. In contrast, lung damage i...Continue Reading

References

Mar 11, 1991·Immunology Today·F D FinkelmanA Sher
Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J F UrbanF D Finkelman
Oct 1, 1989·Cellular Immunology·A O'GarraM Howard
Jun 1, 1970·The Journal of Experimental Medicine·A BastenP B Beeson
Nov 1, 1983·Parasite Immunology·J K CruickshankD A Denham
Feb 1, 1994·The Journal of Experimental Medicine·S DubucquoiM Capron
Dec 1, 1993·International Journal for Parasitology·E A Milbourne, M J Howell

❮ Previous
Next ❯

Citations

Jan 10, 2004·The Journal of Allergy and Clinical Immunology·Amy D Klion, Thomas B Nutman
Apr 3, 2002·Trends in Molecular Medicine·Paul S FosterDianne C Webb
Mar 22, 2003·American Journal of Respiratory and Critical Care Medicine·Johan C KipsRomain A Pauwels
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·R IngK G Koski
Feb 26, 2000·Parasitology Today·E N Meeusen, A Balic
Mar 12, 2015·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Tadashi Kasahara
Feb 24, 2007·Parasitology International·Nobuaki Akao, Nobuo Ohta
Jun 23, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E PinelliJ van der Giessen
Oct 3, 2003·Parasite Immunology·A P RogerioL H Faccioli
Apr 4, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Simon P HoganMarc E Rothenberg
Feb 13, 2010·Annals of Tropical Medicine and Parasitology·G Rubinsky-ElefantM U Ferreira
Jan 29, 2013·Veterinary Parasitology·Rick M Maizels
Mar 23, 2000·Biochimica Et Biophysica Acta·K IshiharaK Ohuchi
Jun 9, 2007·International Journal for Parasitology·Michelle L KnottLindsay A Dent
Jan 4, 2001·The Korean Journal of Parasitology·D N Onah, Y Nawa
Sep 21, 2016·BioMed Research International·Berenice Faz-LópezLuis I Terrazas
Jul 19, 2016·Parasite Immunology·Natalie E Nieuwenhuizen
Dec 25, 2012·Toxicologic Pathology·Susan A ElmoreKatsuhiko Yoshizawa
Jan 1, 1997·Memórias do Instituto Oswaldo Cruz·K I MatthaeiI G Young
Mar 14, 2000·The Journal of Biological Chemistry·L GuoJ C Schuh
Aug 6, 2013·Journal of Toxicologic Pathology·Susan A ElmoreKatsuhiko Yoshizawa
Dec 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bouchaib LamkhiouedPaolo M Renzi
Aug 13, 1999·The American Journal of Physiology·B A VallanceS M Collins
Apr 13, 2019·International Journal for Parasitology. Parasites and Wildlife·Torill MørkSiw T Killengreen
Jun 25, 2021·Seminars in Immunopathology·E Mitre, A D Klion

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.