PMID: 6982790Sep 1, 1982Paper

Eosinophilia VI, spontaneous synthesis of chemokinetics, chemotactic, complement receptor-inducing activities for eosinophils by bronchial t lymphocytes of asthmatic-bronchitic patients

Clinical Allergy
W E Parish, E Luckhurst

Abstract

T lymphocytes were separated from the bronchial mucus of five patients with extrinsic asthma and chronic and mild bronchitis and who had numerous eosinophils in the bronchial mucus but no significant blood eosinophilia. The bronchial lymphocytes spontaneously, that is without treatment with antigens or mitogens, released into serum-free synthetic medium one or more substances in the molecular weight range of 30 000 to 60 000 daltons. These substances when tested on eosinophils of normal persons stimulated random movement (chemokinesis), attracted them (chemotaxis), enhanced their chemotactic response to activated complement, and increased the expression of C4 and C3b receptors. Chemokinetic and chemotactic activity for neutrophils was weak. No eosinophil-stimulating activity was found in cultures of bronchial lymphocytes treated with puromycin to inhibit synthesis. The blood lymphocytes did not spontaneously synthesize the substance(s). It is not known if the several eosinophil-stimulating activities are due to one or more substance(s), but the nature of the eosinophil responses, molecular weight and other features, indicate similarities with the 'eosinophil stimulation promoter-chemotactic' factor reported to be released from ...Continue Reading

References

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Citations

Jan 1, 1990·Molecular Aspects of Medicine·A Shock, G J Laurent
Jan 1, 1997·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·S LanteroG A Rossi
Mar 1, 1990·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J Kus
Feb 1, 1988·The British Journal of Dermatology·C A Bruynzeel-KoomenP L Bruynzeel
Jul 1, 1987·Allergy·A J Wardlaw, A B Kay
Dec 1, 1987·The Journal of Dermatology·C A Bruynszeel-Koomen, P L Bruynzeel
Jan 1, 1993·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·L BusincoM Ferrara
Jan 15, 2011·British Journal of Pharmacology·Philip M HansbroPaul S Foster

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