PMID: 8960312Dec 1, 1996Paper

Eosinophilic bodies in the cerebral cortex of Alzheimer's disease cases

Acta Neuropathologica
M InoueM Matsushita

Abstract

The light microscopical, immunohistochemical and ultrastructural aspects of eosinophilic bodies in the cerebral cortex from patients with Alzheimer's disease (AD) are described, based on a study of 16 cases of AD, 5 elderly non-demented controls and, as disease controls, 5 cases of Pick's disease, 9 with progressive supranuclear palsy, 5 with Creutzfeldt-Jakob disease and 1 with Binswanger's disease. At the light microscopy level, the bodies were clearly separated from the surrounding tissues and were mostly round or elliptic with a diameter of 5-30 microns and a central, intensely eosinophilic core. Ultrastructurally, they consisted of a central homogeneous electron-dense body (HDB), and filamentous structures (resembling either neurofilaments or paired helical filaments) or other small organelles in the periphery. Immunohistochemically, some of these bodies exhibited ring-shaped rims which were positive with antibodies against paired helical filaments, tau-2, phosphorylated neurofilaments and ubiquitin. The bodies were widely distributed throughout the cerebral cortex, but were not observed in the white matter. These bodies were thought to be compatible with one type of axonal dystrophy in the gracile nucleus (termed 'old' sp...Continue Reading

Citations

Apr 14, 1999·Psychiatry and Clinical Neurosciences·K KosakaH Arai
Nov 26, 2002·Pathology International·Takemi KimuraToshinori Kitamura
Nov 12, 2015·PloS One·Kerstin HahnKarin Hultin Jäderlund
Oct 13, 2019·Progress in Neurobiology·Jong-Chan ParkInhee Mook-Jung

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