Eosinophilic disorders: evaluation of current classification and diagnostic criteria, proposal of a practical diagnostic algorithm

Clinical and Translational Allergy
Polliana Mihaela Leru

Abstract

Eosinophilic disorders represent a group of pathologic conditions with highly heterogeneous pathophysiology and clinical presentation and variable prognosis, ranging from asymptomatic or mild, to severe and complex cases, with fatal outcome. Interest in this group of disorders has increased during the last two decades, with consistent progress made regarding understanding of molecular mechanisms, refining of diagnostic criteria, classification and evaluation of therapeutic options. There are still many gaps and difficulties in evaluating eosinophilic syndromes and diseases in medical practice. The disease prognosis depends mainly on the cause and mechanism of eosinophilia, on severity of organ dysfunction and on accurate diagnosis and response to treatment. Besides primary hypereosinophilic syndromes and secondary (reactive) eosinophilias, many associated or idiopathic forms have been described, making this topic a complex and difficult medical entity. An important aim of the experts in the field is to agree upon a more clear and practically useful classification, a better characterization of various phenotypes and endotypes of eosinophilic diseases and to identify novel biomarkers and more effective therapies. The aim of this ...Continue Reading

References

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Citations

May 24, 2020·Cells·Andrius JanuskeviciusKestutis Malakauskas
Jul 29, 2020·Immunological Investigations·Reza KianiSimin Almasi
Feb 3, 2020·Indian Journal of Pediatrics·Sachin SinghPrawin Kumar
Jul 7, 2020·Journal of Thrombosis and Thrombolysis·Ritwick MondalSubhash C Biswas
Dec 10, 2020·Clinical and Translational Allergy·J BousquetM Jutel
Jan 10, 2021·International Journal of Molecular Sciences·Stefania StellaPaolo Vigneri
Apr 23, 2021·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J R BassoL L Cunha
Aug 15, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Gerald J GleichUNKNOWN HES Mepolizumab Study Group

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Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
bone marrow section
flow cytometry

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