Eosinophilic esophagitis -- a mimic of GERD

International Journal of Pediatric Otorhinolaryngology
Richard J Noel, Neelesh Ajit Tipnis

Abstract

Eosinophilic esophagitis (EE) is characterized by eosinophilic infiltration of the esophageal mucosa and results in clinical signs and symptoms that may be indistinguishable from those of gastroesophageal reflux disease (GERD). While demographic, clinical, and endoscopic features may be suggestive of EE, esophageal biopsy with tissue eosinophils averaging 24 per 400 x microscopic field remains the most specific diagnostic criterion. Previously rare, EE has been diagnosed in adults and children with increased frequency over the last decade; it appears to be a chronic disease and has a yearly incidence approximating 1:10,000 in the pediatric population. Dietary and respiratory antigen exposure with subsequent production of inflammatory chemokines is essential for development of EE in animal models of the disease. In humans, glucocorticoids and elimination of relevant dietary antigens have proved efficacious treatments for EE, resolving the disease at the mucosal level. Other therapies, including montelukast, partial dietary elimination, and bouginage have reduced symptoms without affecting mucosal inflammation. Evidence-based guidelines for the management of EE are not currently available. Current medical practice involving the m...Continue Reading

References

Nov 1, 1990·Respiratory Medicine·S M Harding
Dec 1, 1984·The American Journal of Surgical Pathology·L F BrownD A Antonioli
Sep 1, 1995·Abdominal Imaging·K M VitellasJ H Caldwell
Apr 29, 1998·Journal of Pediatric Gastroenterology and Nutrition·C A LiacourasE Ruchelli
Jul 21, 1998·Journal of Pediatric Gastroenterology and Nutrition·W A FaubionD K Freese
Jan 3, 2001·The Journal of Clinical Investigation·A MishraM E Rothenberg
May 17, 2001·Current Gastroenterology Reports·S Vasilopoulos, R Shaker
Jan 22, 2002·The Annals of Otology, Rhinology, and Laryngology·Christopher J HartnickColin Rudolph
Jul 30, 2002·Nature Immunology·Dale T UmetsuRosemarie H DeKruyff
Nov 29, 2002·Archives of Disease in Childhood·G R G ToddD McCance
Jan 9, 2003·Gastrointestinal Endoscopy·Victor L FoxGlenn T Furuta
Mar 4, 2003·Gastrointestinal Endoscopy·Alex StraumannChristoph Beglinger
May 27, 2003·Archives of Disease in Childhood·G R G Todd
Sep 26, 2003·Journal of Pediatric Gastroenterology and Nutrition·Ka Ming CheungChung W Chow
Oct 18, 2003·The Journal of Allergy and Clinical Immunology·Matthew I FoggJonathan M Spergel
Dec 31, 2003·The Journal of Allergy and Clinical Immunology·Jennifer K GarrettMarc E Rothenberg
Mar 16, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Mitchell KaplanAli Keshavarzian
Jun 30, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Richard J NoelMarc E Rothenberg
Sep 28, 2004·Journal of Pediatric Gastroenterology and Nutrition·A M G A Sant'AnnaE Drouin
Feb 8, 2005·The Journal of Allergy and Clinical Immunology·Alex Straumann, Hans-Uwe Simon
May 27, 2005·Respiratory Medicine·Karin C Lødrup CarlsenClaire Wixon

❮ Previous
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Citations

Jul 31, 2009·The Journal of Laryngology and Otology·R HarrisH Daya
Jul 28, 2009·Medicina clínica·Paloma Sánchez-Fayos CalabuigJuan Carlos Porres Cubero
Sep 8, 2009·International Journal of Pediatric Otorhinolaryngology·Lee P SmithKaren B Zur
Sep 8, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Evan S DellonNicholas J Shaheen
Jul 26, 2008·Journal of the Chinese Medical Association : JCMA·Hsueh-Chieh LuFull-Young Chang
Dec 7, 2007·Gastrointestinal Endoscopy Clinics of North America·Seema S AcevesStuart Jon Spechler
May 9, 2008·Histopathology·R Ramakrishnan, H Chong
Jul 23, 2008·Developmental Disabilities Research Reviews·Joan C Arvedson
Jan 15, 2009·Immunology and Allergy Clinics of North America·Seema S Aceves, Steven J Ackerman
Jul 11, 2012·The American Journal of Gastroenterology·Evan S DellonNicholas J Shaheen
Oct 28, 2010·The American Journal of Gastroenterology·Evan S DellonNicholas J Shaheen
Feb 22, 2008·The American Journal of Gastroenterology·Sonali RodrigoParakrama Chandrasoma
Jul 10, 2007·The American Journal of Gastroenterology·Evan S DellonNicholas J Shaheen
May 29, 2007·The American Journal of Gastroenterology·Stuart Jon SpechlerRhonda F Souza
Apr 1, 2010·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·B BasseriJ L Conklin

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