Eosinophilic Esophagitis-A Primer for Otolaryngologists

JAMA Otolaryngology-- Head & Neck Surgery
Sanjay KumarSandeep K Gupta

Abstract

Eosinophilic esophagitis (EoE) is a chronic, inflammatory condition of the esophagus. Prevalence of EoE is on the rise and, owing to its associated extragastrointestinal manifestations and comorbidities, otolaryngologists are increasingly encountering this condition in their practice. Symptoms of EoE are vague and vary greatly based on patient's age. The gastrointestinal symptoms include dysphagia, food impaction, feeding difficulties, symptoms mimicking gastroesophageal reflux, abdominal pain, vomiting, and failure to thrive. Several otolaryngologic symptoms are associated with EoE including rhinosinusitis, chronic cough, recurrent croup, hoarseness, and other aerodigestive symptoms refractory to gastroesophageal reflux therapy. Eosinophilic esophagitis is also frequently associated with other atopic conditions, such as asthma, eczema, and food allergies. The diagnosis is made on endoscopy with biopsies that reveal eosinophil-predominant esophageal inflammation. There are 3 major treatment approaches to EoE, commonly referred to as the 3 Ds: diet, drugs, and dilation. Untreated inflammation of esophagus from EoE can result in irreversible structural damage to the esophagus, leading to fibrosis, strictures, and impaired esophag...Continue Reading

References

Apr 9, 2001·Immunological Reviews·P S FosterD C Webb
Dec 14, 2001·The Journal of Allergy and Clinical Immunology·A StraumannH U Simon
Jan 22, 2002·The Annals of Otology, Rhinology, and Laryngology·Christopher J HartnickColin Rudolph
Aug 27, 2004·The New England Journal of Medicine·Richard J NoelMarc E Rothenberg
Jan 27, 2005·Gastrointestinal Endoscopy·Sonal M Patel, Kenneth R Falchuk
Jun 4, 2005·Gastrointestinal Endoscopy·George W Meyer
Dec 20, 2005·The Annals of Otology, Rhinology, and Laryngology·Eileen H DauerDana M Thompson
Dec 20, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Chris A LiacourasJonathan E Markowitz
Feb 3, 2006·The Journal of Clinical Investigation·Carine BlanchardMarc E Rothenberg
Sep 18, 2007·European Journal of Gastroenterology & Hepatology·Peter NetzerAlain M Schoepfer
Oct 2, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael D KappelmanJonathan A Finkelstein
Dec 7, 2007·Gastrointestinal Endoscopy Clinics of North America·Dana M Thompson, Laura J Orvidas
Feb 2, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Elizabeth T SchaeferSandeep K Gupta
Aug 6, 2008·The Journal of Allergy and Clinical Immunology·Alex StraumannHans-Uwe Simon
Jan 24, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ganesh R VeerappanEric M Osgard
Jul 7, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ganapathy A PrasadNicholas J Talley
Sep 8, 2009·International Journal of Pediatric Otorhinolaryngology·Lee P SmithKaren B Zur
Sep 8, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Evan S DellonNicholas J Shaheen
Nov 26, 2009·The American Journal of Gastroenterology·Alain M SchoepferIkuo Hirano
Mar 9, 2010·Nature Genetics·Marc E RothenbergHakon Hakonarson
Apr 7, 2010·Gastrointestinal Endoscopy·Ikuo Hirano
Oct 27, 2010·Journal of Pediatric Gastroenterology and Nutrition·Christine Waasdorp HurtadoRobert E Kramer
Feb 15, 2011·Therapeutic Advances in Gastroenterology·Jonathan RickerKevin Franklin
Oct 25, 2011·The Journal of Allergy and Clinical Immunology·Petr HruzUNKNOWN Swiss EoE study group
Jan 6, 2012·International Journal of Otolaryngology·Petros D KarkosC Vaughan
Apr 6, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jeffrey A AlexanderNicholas J Talley
Apr 10, 2013·The American Journal of Gastroenterology·Evan S DellonUNKNOWN American College of Gastroenterology
Aug 21, 2013·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Scott HudsonMarshall E Smith
Sep 17, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Evan S DellonMichael D Kappelman
Sep 21, 2013·JAMA Otolaryngology-- Head & Neck Surgery·Courtney A HillChristopher J Hartnick
May 13, 2014·Gastroenterology Clinics of North America·Evan S Dellon
May 13, 2014·Gastroenterology Clinics of North America·Margaret H Collins
May 14, 2014·Journal of Pediatric Gastroenterology and Nutrition·Eitan RubinsteinElizabeth J Hait
Jul 6, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·David A KatzkaRebecca C Fitzgerald
Sep 27, 2014·The Journal of Allergy and Clinical Immunology·Eileen S AlexanderMarc E Rothenberg
Nov 12, 2014·The Annals of Otology, Rhinology, and Laryngology·Elizabeth A KellyRobert H Chun
Nov 20, 2014·Nature Communications·Patrick M A SleimanHakon Hakonarson
Mar 31, 2015·International Journal of Pediatric Otorhinolaryngology·Melanie GreiferLee P Smith

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Citations

Jan 22, 2020·Pediatric Research·Sanjay KumarSandeep K Gupta
Feb 1, 2020·JAMA : the Journal of the American Medical Association·Shai PosnerAmit Patel
Nov 28, 2019·JAMA Otolaryngology-- Head & Neck Surgery·Claire M Lawlor, Sukgi Choi

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