Eosinophilic Esophagitis in Children: Endoscopic Findings at Diagnosis and Post-intervention

Current Gastroenterology Reports
S M BoltonJoshua B Wechsler

Abstract

The goal of this review is to present and summarize studies on endoscopic findings in eosinophilic esophagitis (EoE), at diagnosis and in response to treatment, utilizing rigorous peer-reviewed literature in children wherever possible and to introduce a recently proposed standardized endoscopic evaluation system. Gold standard of diagnosis and assessment of response to therapy in EoE requires multiple endoscopies with biopsies for histology, which allows for observation of the esophageal mucosa. Typical endoscopic findings in patients with EoE include edema, exudate, furrowing, concentric rings, and strictures. Endoscopic findings have been broadly characterized into inflammatory features (edema, exudate, furrowing) and fibro-stenotic features (rings, stricture), in order to better reflect their underlying pathophysiology. Recent studies suggest strong correlations between endoscopic findings, through composite scoring systems, and histology, and therefore may be helpful as part of disease surveillance. The EoE Endoscopic Reference Score (EREFS) classification system was proposed in 2013 as an outcome metric for standardization in reporting endoscopic signs of EoE. Subsequent studies support utility of composite scoring, which ...Continue Reading

References

May 1, 1981·AJR. American Journal of Roentgenology·D Picus, P H Frank
Jul 30, 2002·Gastrointestinal Endoscopy·Victor L FoxGlenn T Furuta
Mar 4, 2003·Gastrointestinal Endoscopy·Alex StraumannChristoph Beglinger
Mar 16, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Mitchell KaplanAli Keshavarzian
Dec 20, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Chris A LiacourasJonathan E Markowitz
Jun 22, 2007·The American Journal of Gastroenterology·Seema S AcevesRanjan Dohil
Jul 10, 2007·The American Journal of Gastroenterology·Evan S DellonNicholas J Shaheen
Sep 4, 2007·The American Journal of Gastroenterology·Ganapathy A PrasadJeffery A Alexander
Oct 9, 2007·Gastroenterology·Glenn T FurutaUNKNOWN First International Gastrointestinal Eosinophil Research Symposium (FIGERS) Subcommittees
Jan 31, 2009·Journal of Pediatric Gastroenterology and Nutrition·Scott PentiukMarc E Rothenberg
Sep 23, 2010·Gastroenterology·Monika A KwiatekJohn E Pandolfino
Apr 12, 2011·The Journal of Allergy and Clinical Immunology·Chris A LiacourasSeema S Aceves
May 23, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Hannah P KimEvan S Dellon
Jun 26, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Evan S Dellon
Nov 28, 2013·Gastrointestinal Endoscopy·Evan S DellonNicholas J Shaheen
Jul 22, 2015·Clinical Reviews in Allergy & Immunology·Antonella Cianferoni, Jonathan Spergel
Sep 26, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Evan S DellonNicholas J Shaheen
Nov 21, 2015·Gastroenterology·Ekaterina SafroneevaUNKNOWN International Eosinophilic Esophagitis Activity Index Study Group
May 11, 2017·Journal of Pediatric Gastroenterology and Nutrition·Jacqueline M FableWael N Sayej
May 17, 2017·The American Journal of Gastroenterology·Calies Menard-KatcherAmanda B Muir
Jun 13, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Amir F KagalwallaMirna Chehade
Dec 19, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Joshua B WechslerAmir F Kagalwalla

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Citations

Jul 18, 2018·Current Opinion in Pediatrics·Aakash Goyal
Dec 14, 2019·Journal of Pediatric Gastroenterology and Nutrition·Anna HendersonPatricia C Fulkerson
Jun 3, 2020·Pediatric Gastroenterology, Hepatology & Nutrition·Kunsong LeeHye Ran Yang
Oct 24, 2021·Gastroenterology·Tetsuo ShodaUNKNOWN Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR) Investigators Group

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