Eosinophilic Esophagitis in Two Patients with Systemic Sclerosis

Case Reports in Rheumatology
Tracy M FrechKathryn Peterson

Abstract

The gastrointestinal tract (GIT) is the most common extracutaneous organ system damaged in systemic sclerosis (SSc) and is the presenting feature in 10% of patients. The esophagus as the portion of the GIT is the most commonly affected and there is an association of gastroesophageal reflux (GER) with SSc interstitial lung disease (ILD). Thus, an aggressive treatment for GER is recommended in all SSc patients with ILD; however, it is recognized that a long-term benefit to this treatment is needed to understand its impact. In this case report we discuss the presence of eosinophilic esophagitis (EoE) in two SSc patients and discuss the role for early EGD in SSc patients with moderate-severe GER symptoms for tissue study. Assessment of esophageal biopsy specimens for the presence of eosinophils and possibly ANA can help elucidate disease pathogenesis and direct therapy, as the presence of EoE in SSc has important management considerations, particularly with regards to dietary modification strategies.

References

Jan 1, 1990·The British Journal of Surgery·R H ParkJ F MacKenzie
Nov 18, 2000·Arthritis and Rheumatism·V D Steen, T A Medsger
Oct 16, 2007·Digestive Diseases and Sciences·Robyn DomsicKlaus Bielefeldt
Dec 20, 2008·American Journal of Respiratory and Critical Care Medicine·Edoardo SavarinoMassimo Ghio
Aug 17, 2010·Rheumatology International·Rene ThonhoferWinfried Graninger
Oct 12, 2010·The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology·Rukiye VardarSerhat Bor
Jul 20, 2011·Rheumatology International·T SchmeiserU Müller-Ladner
Nov 23, 2011·Current Rheumatology Reports·Genevieve Gyger, Murray Baron
Apr 9, 2013·The American Journal of Dermatopathology·Deepti M ReddiPuja K Puri
Apr 10, 2013·The American Journal of Gastroenterology·Evan S DellonUNKNOWN American College of Gastroenterology
Sep 18, 2013·Internal Medicine·Shih-Horng HuangSheng-Hsiang Lin
Sep 21, 2013·Current Opinion in Rheumatology·Dinesh KhannaTracy Frech
Nov 14, 2013·World Journal of Gastroenterology : WJG·Xin-Ping Tian, Xuan Zhang
Apr 24, 2014·Arthritis Care & Research·Tracy M FrechJathine Wong
Aug 12, 2014·Gastroenterology·Evan S Dellon, Chris A Liacouras

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Methods Mentioned

BETA
biopsy
biopsies

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