Eosinophilic esophagitis: latest insights from diagnosis to therapy

Annals of the New York Academy of Sciences
A M SchoepferRoberto Penagini

Abstract

Eosinophilic esophagitis (EoE) represents a chronic, local immune-mediated esophageal disease, characterized clinically by symptoms related to esophageal dysfunction and histologically by eosinophil-predominant inflammation. Other systemic and local causes of esophageal eosinophilia should be excluded. Clinical manifestations or pathologic data should not be interpreted in isolation. EoE was first described as a distinct disease entity in 1993. Most patients are diagnosed with underlying food allergies. The first diagnostic and therapeutic guidelines were published in 2007 with a first update in 2011. In 2017, new international guidelines were published based on the GRADE methodology. These guidelines provide, among many other topics, insights on the role of proton pump inhibitor-responsive esophageal eosinophilia. Over the last two decades, considerable progress was made by stakeholders regarding the understanding of EoE's pathogenesis, genetic background, natural history, allergy workup, standardization of assessment of disease activity, evaluation of minimally invasive diagnostic tools, and new therapeutic approaches. This brief review provides further insights into latest diagnostic and therapeutic advances.

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Citations

Oct 27, 2018·Frontiers in Medicine·Elisa Gomez TorrijosJoan Bartra
Jul 29, 2019·Drugs·Willemijn E de RooijAlbert J Bredenoord
Jul 13, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·J Winny Yun, Mansoureh Barzegar
Feb 23, 2021·Therapeutic Advances in Gastroenterology·Pierfrancesco VisaggiNicola de Bortoli
Jun 3, 2021·Nutrients·Pierfrancesco VisaggiNicola de Bortoli
Jun 13, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Marco Vincenzo LentiAntonio Di Sabatino
Aug 9, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Matteo GhisaEdoardo Savarino

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