Eosinophilic esophagitis: short and long-term considerations

Current Opinion in Pediatrics
Aakash Goyal

Abstract

Eosinophilic esophagitis (EoE) is a relatively new disease but its understanding is evolving over a period of time. This review highlights recent advances in the understanding of pathophysiology, diagnostic modalities, short and long-term goals of therapy and novel therapeutic agents. The prevalence of EoE is increasing. Upper endoscopy and biopsy remains the gold standard for diagnosing EoE but less invasive and more cost-effective testing has been under investigation. Scoring systems to assess symptoms, histology and endoscopic findings can distinguish between active and inactive disease. Step up therapy with 2-4-6 food elimination can result in early identification of triggering foods and reduce frequency of endoscopies. The term proton pump inhibitor (PPI) responsive eosinophilia should be avoided and PPI should be considered a therapeutic modality. Oral viscous budesonide has been more effective than fluticasone in achieving remission. Adrenal suppression should be looked for patients on swallowed steroids. IL-13 antagonists can be a promising therapy for EoE and dilation is a safe and effective treatment modality in patients with EoE but as is expected, does not decrease inflammation. EoE has been increasingly recognized ...Continue Reading

References

May 10, 2003·The American Journal of Gastroenterology·Jonathan E MarkowitzChris A Liacouras
Oct 18, 2003·The Journal of Allergy and Clinical Immunology·Matthew I FoggJonathan M Spergel
Aug 23, 2006·Gastrointestinal Endoscopy·Nirmala GonsalvesIkuo Hirano
Aug 6, 2008·The Journal of Allergy and Clinical Immunology·Alex StraumannHans-Uwe Simon
Jan 28, 2009·Journal of Pediatric Gastroenterology and Nutrition·Jonathan M SpergelChris A Liacouras
Jul 7, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ganapathy A PrasadNicholas J Talley
Dec 18, 2009·Mucosal Immunology·M R Comeau, S F Ziegler
Mar 9, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carine BlanchardMarc E Rothenberg
Sep 23, 2010·Gastroenterology·Monika A KwiatekJohn E Pandolfino
Apr 12, 2011·The Journal of Allergy and Clinical Immunology·Chris A LiacourasSeema S Aceves
May 17, 2011·The Journal of Allergy and Clinical Immunology·Joseph D Sherrill, Marc E Rothenberg
Aug 3, 2011·European Journal of Pediatrics·Ruben RochaJorge Amil Dias
Oct 25, 2011·The Journal of Allergy and Clinical Immunology·Petr HruzUNKNOWN Swiss EoE study group
Dec 31, 2011·The Journal of Allergy and Clinical Immunology·Jonathan M SpergelChris A Liacouras
Jan 17, 2012·American Journal of Respiratory Cell and Molecular Biology·Masaru UchidaKenji Izuhara
May 1, 2012·Gastroenterology·Alex Straumann
May 23, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Hannah P KimEvan S Dellon
Mar 30, 2013·Journal of Pediatric Gastroenterology and Nutrition·Ing S SoonJennifer C C deBruyn
Sep 17, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Evan S DellonMichael D Kappelman
Mar 8, 2014·Digestive Diseases·Seema S Aceves
Apr 25, 2014·Allergology International : Official Journal of the Japanese Society of Allergology·Yukie Yamaguchi
May 13, 2014·Gastroenterology Clinics of North America·Margaret H Collins
Jul 6, 2014·The Journal of Allergy and Clinical Immunology·J Kelley BentleyMarc B Hershenson
Sep 13, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Evan S DellonJohn T Woosley
Sep 18, 2014·The Journal of Allergy and Clinical Immunology·Marc E RothenbergKulasiri A Gunawardena
May 20, 2015·Journal of Pediatric Gastroenterology and Nutrition·Calies Menard-KatcherLaura Z Fenton
Jul 6, 2015·Gastrointestinal Endoscopy·Joel A FriedlanderJeremy D Prager
Oct 22, 2015·The New England Journal of Medicine·Glenn T Furuta, David A Katzka
Dec 20, 2015·Gut·Javier Molina-InfanteUNKNOWN PPI-REE Task Force of the European Society of Eosinophilic Oesophagitis (EUREOS)
May 8, 2016·The American Journal of Medicine·Robert T KavittMichael F Vaezi
Jun 3, 2016·Journal of Pediatric Gastroenterology and Nutrition·Salvatore OlivaSalvatore Cucchiara
Sep 22, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jeffrey A AlexanderDavid A Katzka
Sep 30, 2016·The American Journal of Gastroenterology
Oct 22, 2016·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Alexandra AhmetJanice L Barkey
Nov 20, 2016·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Mahboobeh MahdaviniaAnne M Ditto
Dec 22, 2016·Expert Review of Gastroenterology & Hepatology·Javier Molina-InfanteAlfredo J Lucendo
Jan 6, 2017·Journal of Pediatric Gastroenterology and Nutrition·Calies Menard-KatcherRobert E Kramer
Jan 21, 2017·The Journal of Allergy and Clinical Immunology·Mark RochmanMarc E Rothenberg
Jan 25, 2017·Journal of Pediatric Gastroenterology and Nutrition·Sunpreet KaurJeffrey B Brown
Jan 31, 2017·The Journal of Allergy and Clinical Immunology·Vladislav A LitoshMarc E Rothenberg
Apr 4, 2017·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Jesús González-CerveraAlfredo J Lucendo

❮ Previous
Next ❯

Citations

May 4, 2021·Journal of Pediatric Gastroenterology and Nutrition·Paroma BoseWilliam E Bennett

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

Gastroenterology & Hepatology
Anna M Lipowska, Robert T Kavitt
Current Treatment Options in Gastroenterology
Ronak Vashi Patel, Ikuo Hirano
Expert Review of Gastroenterology & Hepatology
Javier Molina-Infante, A J Lucendo
Current Gastroenterology Reports
Ricardo Prieto, Joel E Richter
Current Gastroenterology Reports
Carol Garrean, Ikuo Hirano
© 2022 Meta ULC. All rights reserved