PMID: 3766526Nov 1, 1986Paper

Eosinophilic fibrohistiocytic lesion of bone marrow associated with monoclonal gammopathy and osteolytic lesions

American Journal of Hematology
A NaglerS Pollack

Abstract

We describe a 63-year-old male patient with severe osteoporosis, multiple lytic bone lesions, and monoclonal gammopathy (IgG lambda). Whereas the tentative diagnosis in this case was multiple myeloma, bone marrow trephine biopsies of the iliac crest and from an osteolytic lesion of the tibia both showed a peculiar infiltrate consisting of numerous elongated mast cells, eosinophils, and some plasma cells and lymphocytes. The bone marrow lesions fit the diagnosis of eosinophilic fibrohistiocytic lesion of bone marrow (EFHBM). The patient had no abnormality that could be related to a known allergic disease, and no relationship to drug hypersensitivity could be established. The features of the bone marrow infiltrate and its association with monoclonal gammopathy may suggest a linkage between EFHBM and the monoclonal gammopathy.

References

Aug 1, 1977·The American Journal of Medicine·A Solomon
Apr 17, 1978·Virchows Archiv. A, Pathological Anatomy and Histology·J te VeldeO L Bijvoet
May 1, 1978·The American Journal of Medicine·R A Kyle
Jan 1, 1977·Acta Medica Scandinavica·U Axelsson
Sep 19, 1968·The New England Journal of Medicine·B Frame, R K Nixon
Apr 1, 1969·The American Journal of Medicine·L P RowlandS Ball
Jan 1, 1980·Acta Haematologica·Y ShoenfeldE Beutler

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Citations

Jan 1, 1988·Critical Reviews in Oncology/hematology·R A Kyle, P A Greipp

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