PMID: 9648956Jul 2, 1998Paper

Eosinophilic inflammation in cough variant asthma

The European Respiratory Journal
Akio NiimiF Kuze

Abstract

Eosinophils are considered to play a central pathogenetic role in asthma. We previously reported that sputum eosinophilia was observed in patients with cough variant asthma (CVA), as well as in "classic" asthma with wheezing. This study was undertaken to further investigate the involvement of eosinophils in CVA. The serum eosinophil cationic protein (ECP) level, the percentage of eosinophils in bronchoalveolar lavage (BAL) fluid, and the number of eosinophils in bronchial biopsy specimen were examined in 14 patients with CVA, 21 with classic asthma, and in seven healthy controls. For the two asthmatic groups, the clinical severity was classified with scores of 1-3. Pulmonary function and bronchial responsiveness were not significantly different between the patients with classic asthma and those with CVA. BAL, tissue eosinophil and serum ECP were all significantly increased in both classic asthma and CVA when compared with the controls but were not different between classic asthma and CVA. In both groups of asthmatics, the clinical severity significantly correlated with serum ECP and tissue eosinophils. In conclusion, eosinophilic inflammation is involved in cough variant asthma as well as in classic asthma. Anti-inflammatory tr...Continue Reading

Citations

Aug 19, 2000·Lancet·A NiimiR Amitani
Oct 5, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Hiroshi KanazawaJunichi Yoshikawa
Aug 27, 2004·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Chang Keun Kim, John B Hagan
May 17, 2000·Current Opinion in Pulmonary Medicine·A Niimi, H Matsumoto
Apr 13, 2005·Respirology : Official Journal of the Asian Pacific Society of Respirology·Masaki FujimuraKeiichi Iwasa
Jun 16, 2005·Respirology : Official Journal of the Asian Pacific Society of Respirology·Kumiko ShirahataShu-Ichi Ikeda
Apr 11, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Li YuCuiqin Shi
Apr 11, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Masaki FujimuraJohsuke Hara
Oct 6, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Mitsuhiro KamimuraKaneyuki Furihata
Sep 30, 2003·Thorax·A H Morice, J A Kastelik
Jul 1, 2011·Therapeutic Advances in Chronic Disease·Jaymin B Morjaria, Jack A Kastelik
Sep 24, 2004·Respiratory Research·Graeme R ZoskyDebra J Turner
Jan 1, 2010·Multidisciplinary Respiratory Medicine·Chiara MagniAlessandro Zanasi
Jun 17, 2008·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Masaki Fujimura
Nov 9, 2010·Medicinski pregled·Ivana StankovićBranislava Milenković
Aug 16, 2014·American Journal of Respiratory and Critical Care Medicine·Yoshihiro KanemitsuMichiaki Mishima
Aug 13, 2011·Clinical Reviews in Allergy & Immunology·Valerie L MitchellLaurel J Gershwin
Mar 22, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Q LiuM Yasui
Dec 22, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M FujimuraT Matsuda
Dec 22, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C E Brightling, I D Pavord
Oct 21, 2014·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Etsuko TagayaJun Tamaoki
Mar 7, 2006·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Hisako MatsumotoMichiaki Mishima
Feb 11, 2005·Experimental Lung Research·Masaru NishitsujiShinji Nakao
Apr 4, 2015·Journal of Psychosomatic Research·Norihiro SaitoHiroyuki Kayaba
May 14, 2011·Current Opinion in Pharmacology·Scott E Turcotte, M Diane Lougheed
Feb 5, 2011·Pulmonary Pharmacology & Therapeutics·Akio Niimi
Jan 6, 2009·Pulmonary Pharmacology & Therapeutics·Akio NiimiMichiaki Mishima
Apr 22, 2008·Lancet·Kian Fan Chung, Ian D Pavord
Mar 21, 2007·Pulmonary Pharmacology & Therapeutics·Masaru NishitsujiShinji Nakao
Dec 16, 2006·Pulmonary Pharmacology & Therapeutics·Akio Niimi
Dec 18, 2013·Lung·Akio NiimiPeter V Dicpinigaitis
Jul 13, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R ChaudhuriN C Thomson
Jun 4, 2005·Allergy·V Cottin, J-F Cordier
Oct 2, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C K KimY Y Koh
May 20, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M FujimuraS Nomura

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.