Eosinophilic myocarditis in a patient with idiopathic hypereosinophilic syndrome: insights into mechanisms of myocardial cell death

Human Pathology
Domenico CorradiCarlo Buzio

Abstract

Idiopathic hypereosinophilic syndrome (HES) consists of a prolonged state of eosinophilia of unknown origin with organ involvement. We describe the case of a patient who developed fatal eosinophilic myocarditis. A 23-year-old woman with an 8-month history of eosinophilia presented with symptoms of myocarditis. Histological evaluation of an endomyocardial biopsy specimen revealed marked endomyocardial eosinophilic infiltration with eosinophil-rich granulomas and areas of myocyte necrosis. A terminal deoxynucleotidil transferase assay revealed apoptosis in several cardiomyocytes and vascular cells, mainly in the myocardial areas with higher eosinophil density. Evaluation of an endomyocardial biopsy specimen obtained after steroid therapy demonstrated that the eosinophils had disappeared, but there was marked myocardiosclerosis and scattered apoptotic cells. The patient slowly developed heart failure and died of sudden arrhythmic death. HES can cause severe myocarditis with extensive myocyte loss, probably due to both necrosis and apoptosis. Myocardial fibrosis may occur despite treatment, and patients may be at risk for fatal arrhythmias.

References

Apr 17, 1997·The New England Journal of Medicine·G OlivettiP Anversa
Jun 27, 2000·The American Journal of Cardiology·S R OmmenA J Tajik
May 17, 2003·The Journal of Clinical Investigation·Bernardo Nadal-GinardAnnarosa Leri

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Citations

Sep 28, 2005·Nature Clinical Practice. Cardiovascular Medicine·Leslie T Cooper, Kenton J Zehr
Apr 10, 2009·The New England Journal of Medicine·Leslie T Cooper
Nov 2, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Domenica MangieriAugusto Vaglio
Jul 5, 2005·Acta Haematologica·A Tefferi
Apr 13, 2011·International Heart Journal·Tomoyoshi YanagisawaTohru Izumi
Oct 18, 2014·The American Journal of the Medical Sciences·Samuel T CoffinLisa A Mendes
Jun 12, 2009·Kidney International·Augusto VaglioCarlo Buzio
Dec 8, 2006·The Canadian Journal of Cardiology·Abdullah M Al AliAndrew P Ignaszewski
Mar 6, 2015·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Tomasz Miszalski-JamkaJacek Musiał
Apr 28, 2009·La Revue de médecine interne·J-C EicherJ-E Wolf
Apr 25, 2007·The Journal of Allergy and Clinical Immunology·Alexandra BöhmPeter Valent
Mar 28, 2007·Heart Failure Clinics·Navneet Narula, Dennis M McNamara
Mar 28, 2007·Heart Failure Clinics·Fredric Ginsberg, Joseph E Parrillo
Jun 4, 2005·Allergy·V Cottin, J-F Cordier
Jan 24, 2006·Human Pathology·Keisuke IshizawaTakanori Hirose
Apr 11, 2015·Archives of Cardiovascular Diseases·Pierre-Emmanuel SéguélaJean-Benoit Thambo
Dec 17, 2014·Autoimmunity Reviews·Antonio GrecoMarco De Vincentiis
Nov 19, 2014·Frontiers in Immunology·Andrea GioffrediCarlo Buzio
Mar 18, 2017·The Journal of Experimental Medicine·Nicola L DinyDaniela Čiháková
Sep 5, 2006·La Revue de médecine interne·K AissiY Francès
Jan 6, 2009·Pediatric Cardiology·Matthew D FilesStephen M Langley
Nov 15, 2006·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Yuichi MiyakeMasakazu Kohno
Nov 1, 2005·Zeitschrift für Kardiologie·M HuntgeburthU C Hoppe
Apr 22, 2010·Journal of Cardiovascular Medicine·Caroline Bleakley, David McEneaney
May 1, 2013·The American Journal of Forensic Medicine and Pathology·Butch HustonMichael McGee
Oct 22, 2014·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Zhi-Ping GuoYao-Fang Zhang
Dec 12, 2012·International Urology and Nephrology·Sachin B PatilHargovind L Trivedi
Aug 18, 2006·The Korean Journal of Internal Medicine·Il Suk SohnJeong Gwan Cho
May 13, 2017·Frontiers in Immunology·Nicola L DinyDaniela Čiháková
Jun 27, 2021·Heart·Antoine BondueFlorence Roufosse

❮ Previous
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