PMID: 8592054Oct 1, 1995Paper

Eosinophilic neuronal inclusions in the thalamus of ageing B6C3F1 mice

Journal of Comparative Pathology
T YanaiN Goto

Abstract

The age-related incidence of thalamic neuronal inclusions in the brains of aged B6C3F1 mice and their histopathological and ultrastructural features were studied. Round to oval or rod-shaped eosinophilic inclusions, which were frequently observed in the neurons of the thalamic area, were stained positively with phosphotungstic acid haematoxylin. The inclusions were detected first at 32 weeks of age and the incidence and severity were higher in older animals, all of the mice being affected after 58 weeks of age. Ultrastructurally, the inclusions appeared as sheaves of parallel osmiophilic filaments in the perikaryon of the neurons in the thalamus. Thus thalamic neuronal inclusions in mice seem to be age-related, but their significance remains unclear.

References

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Oct 1, 1984·Nihon juigaku zasshi. The Japanese journal of veterinary science·T YanaiN Matsunuma

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Citations

Dec 13, 2000·Experimental Gerontology·M JuckerD K Ingram
Mar 3, 2010·Journal of the American Animal Hospital Association·Rebecca L MurraySharon D Gottfried
Apr 28, 2006·Neuroreport·Allan KalueffPentii Tuchimaa
Jul 6, 2019·Veterinary Pathology·James C TarrantEnrico Radaelli
Feb 10, 2021·Australian Veterinary Journal·L K ManningR W Cook

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