Eosinophilic oesophagitis: relevance of mast cell infiltration

Histopathology
Daniel S StrasserAlex Straumann

Abstract

Eosinophilic oesophagitis (EoE) is a chronic inflammatory disease characterised clinically by symptoms of oesophageal dysfunction and histopathologically by a prominent eosinophilic inflammation. Despite eosinophils having a histologically predominant position, their role in the immunopathogenesis of the disease is still questionable. Several other inflammatory cells are involved and may also play a critical role. The purpose of this study was to characterise the mast cell infiltration, and to correlate it with the clinical state of EoE. Using immunohistochemistry and quantitative morphometry, we investigated eosinophils and mast cells extensively in oesophageal biopsies from patients with active EoE and from patients with EoE in remission, and compared the findings with healthy individuals. In EoE, epithelium and lamina propria were similarly infiltrated with eosinophils. In contrast, mast cells infiltration was limited to the epithelium, displaying a localised immune response. Interestingly, whereas epithelial mast cells and eosinophils were high in active EoE, some patients in remission, e.g. normalised epithelial eosinophils, showed remaining high numbers of mast cells. Patient clustering supported two groups of patients in...Continue Reading

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Citations

Nov 6, 2018·Expert Review of Clinical Immunology·Melanie A RuffnerAntonella Cianferoni
Dec 15, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Flávia Márcia de Castro E SilvaAna Paula Ferreira
Feb 6, 2020·PLoS Computational Biology·Manuel StrittEnrico Vezzali
Mar 13, 2020·Expert Review of Clinical Immunology·Salvatore OlivaMarc E Rothenberg
Apr 6, 2020·Digestive Diseases and Sciences·Benjamin L WrightEvan S Dellon
Dec 14, 2018·Frontiers in Immunology·Benjamin L WrightR Sharon Chinthrajah
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Jun 29, 2021·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Shaina H HasanShauna Schroeder

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