PMID: 3753540Sep 1, 1986Paper

Eosinophilic synovitis: clinical observations on a newly recognized subset of patients with dermatographism

Arthritis and Rheumatism
J BrownH A Ménard

Abstract

Eosinophilia of synovial fluid is uncommon. Using the identification of Charcot-Leyden crystals to alert for the presence of eosinophils, we have increased by a factor of 5 the detection rate of synovial fluid eosinophilia. We describe here our clinical and laboratory findings in 7 patients with this feature. We believe they constitute a defined syndrome. Typically, the patients were young (ages 18-51) and had a personal and family history of allergy. They developed an acute, painless monarthritis after a minor trauma, and had no concurrent allergic symptoms. Each episode resolved in 1-2 weeks without therapy, and 3 patients had recurrences. All had pronounced dermatographism. The synovial fluid was mildly inflammatory: 10,850 +/- 3,665 white blood cells/mm3, with 41 +/- 5% eosinophils (mean +/- SEM). The cellularity and chemistry of the peripheral blood was unremarkable, except for a mild elevation of IgE levels (370 +/- 104 IU/ml). The exact pathophysiologic mechanism underlying this benign entity is not clear, but we suspect a nonimmunologic triggering event is operant, i.e., synovial trauma which mimics the cutaneous dermatographism.

References

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Citations

Jan 1, 1987·Rheumatology International·D J McNeilM J Fritzler
Oct 9, 2012·Rheumatology·Caritina Vázquez-TriñanesCésar Martínez-Vázquez
Oct 1, 1994·Cytopathology : Official Journal of the British Society for Clinical Cytology·T KüpperP Pfitzer
May 1, 1990·Equine Veterinary Journal·A S TurnerM A Thrall
Jan 1, 1996·Scandinavian Journal of Rheumatology·A AtanesF Galdo
Feb 1, 1989·Seminars in Arthritis and Rheumatism·A J Reginato, B Kurnik
Jul 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J H ButterfieldG J Gleich
Nov 1, 1988·Arthritis and Rheumatism·J KayH R Schumacher
Nov 1, 1987·Arthritis and Rheumatism·B AmorM Dougados
Apr 16, 2021·Journal of the American Veterinary Medical Association·Amy E DiDomenicoDevorah M Stowe

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