Eosinophilic ulcer: the role of stress-induced psychoneuroimmunologic factors.

Oral and Maxillofacial Surgery
André Luis Ribeiro RibeiroJoão de Jesus Viana Pinheiro

Abstract

Eosinophilic ulcer (EU) is a rare pathology and its etiology is still slightly known. It is a benign lesion characterized by fast-growing ulceration with elevated and indurated borders, most commonly affecting the tongue. The authors describe a case of EU on a lingual border that was initiated and had its clinical behavior altered by the psychological stress the patient was experiencing. This paper discusses the stress effects that alter the individual's immunologic response, thus attracting mast cells and eosinophils towards the mucosal epithelium, which are involved in eosinophilic ulcer. The authors make an association between eosinophilic ulcer and atopic dermatitis, two diseases that appear to have a similar, though not fully defined, etiology. The psychological stress factor was considered a predisponent factor for eosinophilic ulcer etiology and its interference in the etiology and evolution of this disease should be considered.

References

Jun 1, 1993·Oral Surgery, Oral Medicine, and Oral Pathology·S K el-MoftyA S Miller
Aug 6, 2002·Journal of Neuroimmunology·A Buske-KirschbaumD H Hellhammer
Aug 23, 2005·Dermatologic Clinics·Mauro UrpeTorello Lotti
Oct 25, 2007·The Australasian Journal of Dermatology·Simin AdaUnser Arikan
Jul 16, 2008·Seminars in Cutaneous Medicine and Surgery·Elif Dokmeci, Christina A Herrick

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