Eosinophils and the granulomatous reaction in rats injected with Sephadex particles

Pulmonary Pharmacology
R M CookH Smith

Abstract

Treatment of rats with a single intravenous injection of 0.5 mg Sephadex G200 caused a blood and lung eosinophilia first detected on day 2, peaking on day 7 and declining to control levels by days 28 and 84 respectively. The increase in eosinophil numbers was accompanied by the development of pulmonary granulomas reaching their maximum size 2-7 days after Sephadex treatment and persisting for 84 days. This reaction was characterised by an early infiltration with polymorphonuclear leucocytes followed by increased numbers of mononuclear cells. Few eosinophils were associated with the Sephadex particles but large numbers were found in the adventitial layers of the lung. There was an increase in the size of the granulomas in rats given Sephadex on days 0, 2 and 5 compared with the response in rats given a single injection of Sephadex. The inflammation was more intense and more eosinophils were detected in the blood, alveolar tissues and adventitia. The effects of drugs given before each injection of Sephadex were evaluated. Dexamethasone, dapsone and isoprenaline reduced the blood and tissue eosinophilia but had no effect on the number of granulomas. Dexamethasone and dapsone, but not isoprenaline caused a slight reduction in the s...Continue Reading

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Citations

Jul 1, 1993·Agents and Actions·V PiercyB A Spicer
Nov 7, 1996·European Journal of Pharmacology·M T NamovicR L Bell
Aug 15, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G C Hard
Sep 1, 1990·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R M Cook
Dec 1, 1990·British Journal of Pharmacology·B A SpicerH Smith
Jan 1, 1991·Annals of the New York Academy of Sciences·T J WilliamsS Nourshargh
Jun 1, 1996·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·R KleemannF Hartig
Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·El-Bdaoui HaddadMaria G Belvisi
May 11, 2010·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Alexandre P RogerioLúcia H Faccioli

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