Eosinophils and Trichinella infection: toxic for the parasite and the host?

Trends in Parasitology
F BruschiNaohiro Watanabe

Abstract

Peripheral blood and tissue eosinophilia characterize trichinellosis in humans, and present in addition to the increased total IgE levels that occur in many helminth infections. Both processes are the consequence of T-helper 2 activation. Blood and tissue eosinophilia begins with eosinophilopoiesis in the bone marrow, which is followed by the migration of eosinophils through the circulatory system, the eosinophil infiltration of tissues at the inflammatory foci and, finally, degranulation and cell death. Recently, some aspects of eosinophilia caused by Trichinella spiralis infection have been elucidated; however, the protective role of this population of cells against Trichinella parasites remains controversial. Furthermore, when eosinophils are numerous, they can be toxic for host tissues. This review discusses these issues in both human and rodent infection models.

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Citations

Mar 25, 2011·Parasites & Vectors·Fabrizo Bruschi, Lorena Chiumiento
Dec 29, 2010·Foodborne Pathogens and Disease·Raul NeghinaIoan Iacobiciu
Mar 12, 2010·Veterinary Parasitology·Robin J FlynnHany M Elsheikha
Dec 17, 2009·Trends in Parasitology·Fabrizio Bruschi
Mar 13, 2015·Journal of Helminthology·G Ortega-PierresR Argüello-García
Aug 15, 2014·Acta Parasitologica·Jarosław KocięckiWanda Kocięcka
Dec 18, 2013·Parasitology International·Naohiro Watanabe
Jun 2, 2011·Experimental Parasitology·Dalia S Ashour, Reda H Elbakary
Jan 13, 2018·The Korean Journal of Parasitology·José Luis Muñoz-CarrilloMaría Alejandra Moreno-García
Nov 4, 2009·The Korean Journal of Parasitology·Myeong Heon ShinDuk-Young Min
Sep 22, 2020·Journal of Helminthology·Jing DingXuelin Wang
Apr 30, 2021·Parasite Immunology·José Luis Muñoz-CarrilloMaría Alejandra Moreno-García
Jun 3, 2021·Diagnostics·Elena Cecilia RoscaMihaela Simu
Jun 25, 2021·Seminars in Immunopathology·E Mitre, A D Klion

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