PMID: 11917220Mar 28, 2002Paper

Eosinophils as a marker for invasion in cervical squamous neoplastic lesions

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Gregory W SpiegelJohn J S Brooks

Abstract

A study of eosinophils associated with cervical neoplastic squamous epithelium was undertaken to determine whether their presence is a marker for invasion. Forty cervical incisional biopsy specimens of high-grade squamous intraepithelial neoplasia (HSIL), 12 with an element of invasive carcinoma, and 2 of HSIL suspicious for invasion, and follow-up excisional specimens of 27 cases of HSIL and 6 of microinvasive and invasive carcinoma were reviewed. In both incisional biopsy and excisional specimens, the presence of >or=5 eosinophils/high-power fields (hpf) and >or=10 eosinophils/10 hpf were both highly significantly associated with invasion with a high degree of specificity and positive predictive value, whereas counts below these thresholds had a high negative predictive value. The authors propose: 1) eosinophil counts in cervical incisional biopsy specimens of >or=5/hpf and/or >or=10/10 hpf warrant a note of caution that invasion may be present even when none is identified in the specimen by conventional criteria; 2) eosinophil counts of >or=5/hpf and/or >or=10/10 hpf in excisional biopsy and hysterectomy specimens should raise the suspicion of invasion in cases in which only HSIL is identified in the initial sections, and wa...Continue Reading

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Citations

Mar 28, 2002·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Gregory W Spiegel
Mar 22, 2003·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Sarla AgarwalGeeta Gupta
Jan 6, 2010·Journal of Oncology·C P Martinelli-KläyT Lombardi
May 5, 2010·International Journal of Biological Sciences·Aijun Liu, Lixin Wei
Dec 18, 2012·Histopathology·Lynn HirschowitzRichard J Zaino
Sep 10, 2005·Best Practice & Research. Clinical Obstetrics & Gynaecology·A J Tiltman
May 24, 2005·La Revue de médecine interne·R CostelloG Sébahoun
Apr 4, 2013·BMC Health Services Research·Marta Aranda-GallardoAna M Mora-Banderas
Jul 18, 2020·Nature Reviews. Cancer·Sharon Grisaru-TalAriel Munitz

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