PMID: 11917219Mar 28, 2002Paper

Eosinophils as a marker for invasion in vulvar squamous neoplastic lesions

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Gregory W Spiegel

Abstract

A study of eosinophils directed against vulvar neoplastic squamous epithelium was undertaken to determine whether there were thresholds per high-power field (hpf) or 10 hpf that were a marker for invasion. The presence of stromal and intraepithelial eosinophils in 33 cases of vulvar grade 3 squamous intraepithelial neoplasia (carcinoma in situ) (VIN 3) was compared with that in 38 cases of vulvar invasive carcinoma with any degree of invasion (ISC). In both incisional biopsy and excisional specimens, the presence of >3 eosinophils per high-power field (eos/hpf) and the presence of >or=5 eosinophils per 10 high-power fields (eos/10 hpf) were both significantly associated with invasion, and the presence of >or=20 eos/hpf and/or >50 eos/10 hpf was limited to cases with invasion. The presence of eosinophils within the neoplastic squamous epithelium was also limited to cases with invasion. The author proposes: 1) eosinophil counts in vulvar incisional biopsy specimens of >3/hpf and/or >or=5/10 hpf warrant a note of caution that invasion may be present even when none is identified by conventional criteria; 2) eosinophil counts of >3/hpf and/or >or=5/10 hpf in excisional specimens should raise the suspicion of invasion in cases in whi...Continue Reading

References

Apr 1, 1988·British Journal of Obstetrics and Gynaecology·D G Lowe
Mar 1, 1985·Gynecologic Oncology·J BoyceJ C Remy
Nov 1, 1985·Gynecologic Oncology·J Menczer
Jun 15, 1981·Cancer·S G Bostrom, W R Hart
Mar 28, 2002·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Gregory W SpiegelJohn J S Brooks
Mar 1, 1961·Cancer·J R GOSLINGT D LOUGHRIN

❮ Previous
Next ❯

Citations

Nov 16, 2005·Clinical Obstetrics and Gynecology·Mario PretiMarc Van Beurden
Jan 6, 2010·Journal of Oncology·C P Martinelli-KläyT Lombardi
May 5, 2010·International Journal of Biological Sciences·Aijun Liu, Lixin Wei
May 24, 2005·La Revue de médecine interne·R CostelloG Sébahoun

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.