Eosinophils in the gastrointestinal tract and their role in the pathogenesis of major colorectal disorders

World Journal of Gastroenterology : WJG
Alexandre Loktionov

Abstract

Eosinophils are currently regarded as versatile mobile cells controlling and regulating multiple biological pathways and responses in health and disease. These cells store in their specific granules numerous biologically active substances (cytotoxic cationic proteins, cytokines, growth factors, chemokines, enzymes) ready for rapid release. The human gut is the main destination of eosinophils that are produced and matured in the bone marrow and then transferred to target tissues through the circulation. In health the most important functions of gut-residing eosinophils comprise their participation in the maintenance of the protective mucosal barrier and interactions with other immune cells in providing immunity to microbiota of the gut lumen. Eosinophils are closely involved in the development of inflammatory bowel disease (IBD), when their cytotoxic granule proteins cause damage to host tissues. However, their roles in Crohn's disease and ulcerative colitis appear to follow different immune response patterns. Eosinophils in IBD are especially important in altering the structure and protective functions of the mucosal barrier and modulating massive neutrophil influx to the lamina propria followed by transepithelial migration to ...Continue Reading

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Citations

Sep 30, 2020·Expert Review of Gastroenterology & Hepatology·Mukaddes TozluAtilla Ertan
Feb 28, 2020·World Journal of Gastroenterology : WJG·Shi-Tong WangLi-Xuan Sang
Sep 12, 2020·Journal of Medical Virology·Yingzheng TanYunzhu Long
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Dec 16, 2020·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Yoko KogureYi Dai
Dec 30, 2020·International Journal of Molecular Sciences·Reyes Gamez-BelmonteChristoph Becker
Mar 10, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Thea MagroneEmilio Jirillo
May 1, 2021·Seminars in Immunopathology·Alessandra GurtnerIsabelle C Arnold
Jun 30, 2021·Life Science Alliance·Hemanth Kumar KandikattuAnil Mishra
Jun 14, 2021·Journal of Comparative Pathology·Antonia Morey-MatamalasKerstin Baiker
Jul 3, 2021·International Journal of Molecular Sciences·Bastian Schirmer, Detlef Neumann
Jul 3, 2021·International Journal of Molecular Sciences·José M Rodrigo-MuñozVictoria Del Pozo
May 26, 2021·Infection and Immunity·Sean M CallahanJeremiah G Johnson
Oct 8, 2021·Scandinavian Journal of Gastroenterology·Marie StruffertAnjona Schmidt-Choudhury

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biopsy
xenograft

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