Eotaxin-1 (CCL11) up-regulation in tears during seasonal allergic conjunctivitis

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Simone EperonYan Guex-Crosier

Abstract

To compare in-season eotaxin-1 levels in tears of patients suffering from seasonal allergic conjunctivitis (SAC) with (1) tears of normal subjects and (2) tears of SAC patients out of season. Tears of 11 SAC patients and six control volunteers were collected during the pollen season. Tears of five SAC patients showing a strong sensitivity to grass pollen (skin-prick tests and specific serum IgE) were collected both in season and out of season. ELISA measured eotaxin-1 level. Eotaxin-1 concentration in tears of SAC patients [2,100+/-503 (SEM) pg/ml] and normal subjects (1,193+/-176 pg/ml) were significantly different (P=0.0049). Regarding allergic patients, the clinical score (sum of five allergic criteria) was significantly different in season and out of season (P=0.0043) as was also the case with eotaxin-1 concentration (P=0.024). The eotaxin-1 concentration in tears of patients showing hay fever could confirm a diagnosis of seasonal ocular allergy.

References

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Citations

Jul 31, 2013·Experimental Eye Research·Andrea Leonardi
Jun 12, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Simone EperonYan Guex-Crosier
Aug 27, 2010·Acta Ophthalmologica·Ester CarreñoMargarita Calonge
Jul 14, 2012·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Tsutomu IgarashiHiroshi Takahashi
May 3, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Tomer AdarEran Goldin
Sep 1, 2007·Proteomics. Clinical Applications·Kaili Wu, Yanli Zhang
Sep 16, 2006·The Journal of Pharmacology and Experimental Therapeutics·Sarah MainTristan J Vaughan

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