EPA and DHA Fatty Acids Induce a Remodeling of Tumor Vasculature and Potentiate Docetaxel Activity.

International Journal of Molecular Sciences
Caroline GoupilleKarine Mahéo

Abstract

n-3 long chain Polyunsaturated Fatty Acids (n-3 LCPUFA) have been shown to improve the efficacy of conventional chemotherapies used for breast cancer treatment. In addition to their reported ability to increase the chemosensitivity of cancer cells, we hypothesized that n-3 LCPUFA could induce a remodeling of the vascular network in mammary tumors. A contrast-enhanced ultrasound method was used to monitor the vascular architecture during docetaxel treatment of mammary tumors in rats fed either a control or an n-3 LCPUFA-enriched diet (docosahexaenoic acid (DHA)/eicosapentaenoic acid (EPA)). The vascular network was remodeled in favor of smaller vessels (microvascularization), which represented 54% of the vasculature in n-3 LCPUFA tumors but only 26% in control tumors after 2 weeks of chemotherapy. Importantly, vascularization changes occurred both before and during docetaxel treatment. The density of smaller vessels quantified before chemotherapy was correlated with improved tumor size reduction by docetaxel treatment. Furthermore, transcript levels of the angiogenesis-specific genes epiregulin and amphiregulin were reduced by ~4.5- and twofold in tumors obtained from rats fed an n-3 LCPUFA-enriched diet compared to those of rat...Continue Reading

References

Feb 15, 2001·Echocardiography·Michel Schneider
Apr 25, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Masako TsujiIkuo Morita
Jun 5, 2003·Nature Medicine·Rakesh K Jain
Oct 29, 2004·Nature Reviews. Cancer·Carl-Henrik HeldinArne Ostman
Jan 22, 2005·Current Opinion in Genetics & Development·Peter BalukDonald M McDonald
Jul 11, 2006·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Philip C Calder
Oct 6, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Séverine ColasPhilippe Bougnoux
Jun 15, 2007·Microvascular Research·Dai Fukumura, Rakesh K Jain
Aug 11, 2007·Bioscience, Biotechnology, and Biochemistry·Tsuyoshi TsuzukiTeruo Miyazawa
Jan 12, 2008·Molecular Cancer Therapeutics·An ClaesWilliam P J Leenders
Jul 8, 2008·The Journal of Nutritional Biochemistry·Patricia D BiondoCatherine J Field
May 9, 2009·International Journal of Molecular Medicine·M L Dos SantosM A Nagai
Sep 1, 2009·Progress in Lipid Research·Philippe BougnouxStephan Chevalier
Sep 10, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bart JacobsSabine Tejpar
Jun 2, 2011·Nature Reviews. Drug Discovery·Peter Carmeliet, Rakesh K Jain
Jun 10, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ingeborg TinhoferUlrich Keilholz
Jun 11, 2011·Biochimica Et Biophysica Acta·Benoit BusserAmandine Hurbin
Mar 7, 2012·Cold Spring Harbor Perspectives in Medicine·Shom GoelRakesh K Jain
Mar 23, 2012·Breast Cancer Research and Treatment·Karine MahéoCaroline Goupille
Apr 5, 2013·Proceedings of the National Academy of Sciences of the United States of America·Guodong ZhangBruce D Hammock
May 15, 2013·The Proceedings of the Nutrition Society·Philip C Calder
Nov 23, 2013·Cancer Research·Yuhui HuangRakesh K Jain
Mar 19, 2014·Seminars in Cell & Developmental Biology·David J Riese, Richard L Cullum
Mar 12, 2015·Scientific Reports·Andrea WeissPatrycja Nowak-Sliwinska
Jul 22, 2015·Journal of Cancer Research and Clinical Oncology·Ji-Won KimIn Ae Park

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Citations

Mar 7, 2021·Marine Drugs·Marine RemizeEdith Filaire
Aug 28, 2021·Nutrients·Giuseppina AugimeriDaniela Bonofiglio

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Methods Mentioned

BETA
X-ray
PCR

Software Mentioned

Visilog
MATLAB
GraphPad Prism

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