Ephaptic transmission from type ii afferents to static γ and β efferents causes complex repetitive discharge: An hypothesis

Muscle & Nerve
Juhani V Partanen

Abstract

Complex repetitive discharges (CRDs) are thought to result from depolarization of a single denervated muscle fiber, followed by ephaptic spread to adjacent fibers. This leads to cyclic spread of the depolarization to produce a recurrent discharge. Another explanation is suggested. CRDs were recorded with single and multiple electromyographic needles longitudinal to muscle fibers in 39 neuropathy patients. The mean frequency of CRDs was 26 Hz, mean number of negative spikes was 5.4, and blocking of spikes occurred in 53% of CRDs. In multi-needle recordings most CRDs were local, but propagation of the discharge was sometimes observed. The prevailing hypothesis of CRDs cannot explain local CRDs. Type II afferents of bag2 and chain fibers branch widely in the juxtaequatorial region of muscle spindles where they may intermingle with motor terminals. Ephaptic transmission from type II afferents to static γ and β efferents may cause CRDs and fix the CRD frequency.

References

Jun 1, 1989·Brain : a Journal of Neurology·M J Zwarts, T W van Weerden
Jan 1, 1972·Brain : a Journal of Neurology·M Swash
Feb 1, 1966·Archives of Neurology·W J Gardner
Feb 1, 1971·Journal of the Neurological Sciences·A A Eisen, G Karpati
Aug 1, 1983·Neurology·J V Partanen, U Nousiainen
Apr 1, 1983·Journal of Neurology, Neurosurgery, and Psychiatry·J Trontelj, E Stålberg
Apr 1, 1983·Journal of Neurology, Neurosurgery, and Psychiatry·J Trontelj, E Stålberg
Mar 20, 1999·Journal of Physiology, Paris·J Partanen
Mar 1, 1965·The Journal of Physiology·M N ADAL, D BARKER
Dec 4, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·T TorbergsenE Stålberg
Nov 1, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·João CostaMamede de Carvalho
Jan 16, 2009·Muscle & Nerve·Jasper R Daube, Devon I Rubin
Aug 26, 2009·Muscle & Nerve·Ernest Johnson
Jun 23, 2015·Journal of Anatomy·Robert W Banks
Jul 17, 2015·Journal of Anatomy·Lars-Eric ThornellFatima Pedrosa-Domellöf

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Citations

May 21, 2017·Skeletal Muscle·Joe N Kornegay
Jun 11, 2020·Brain Sciences·Andreas PosaMalte E Kornhuber

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