EphB4 provides survival advantage to squamous cell carcinoma of the head and neck

International Journal of Cancer. Journal International Du Cancer
R MasoodParkash S Gill

Abstract

The receptor tyrosine kinase EphB4 and its ligand EphrinB2 play critical roles in blood vessel maturation, and are frequently overexpressed in a wide variety of cancers. We studied the aberrant expression and biological role of EphB4 in head and neck squamous cell carcinoma (HNSCC). We tested the effect of EphB4-specific siRNA and antisense oligonucleotides (AS-ODN) on cell growth, migration and invasion, and the effect of EphB4 AS-ODN on tumor growth in vivo. All HNSCC tumor samples express EphB4 and levels of expression correlate directly with higher stage and lymph node metastasis. Six of 7 (86%) HNSCC cell lines express EphB4, which is induced either by EGFR activation or by EPHB4 gene amplification. EphrinB2 was expressed in 65% tumors and 5 of 7 (71%) cell lines. EphB4 provides survival advantage to tumor cells in that EphB4 siRNA and AS-ODN significantly inhibit tumor cell viability, induce apoptosis, activate caspase-8, and sensitize cells to TRAIL-induced cell death. Furthermore, EphB4-specific AS-ODN significantly inhibits the growth of HNSCC tumor xenografts in vivo. Expression of EphB4 in HNSCC tumor cells confers survival and invasive properties, and thereby provides a strong rationale for targeting EphB4 as novel ...Continue Reading

References

Jun 19, 1991·International Journal of Cancer. Journal International Du Cancer·J H LeonardN K Hayward
Jun 22, 1995·International Journal of Cancer. Journal International Du Cancer·A K el-NaggarJ G Batsakis
Sep 24, 1996·Biochemical and Biophysical Research Communications·G BerclazM R Crompton
Oct 23, 1997·Current Opinion in Cell Biology·E B Pasquale
Aug 17, 1999·Current Opinion in Genetics & Development·C Tickle, M Altabef
Sep 30, 1999·International Journal of Cancer. Journal International Du Cancer·D J EastyD C Bennett
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·Y Yarden, M X Sliwkowski
May 18, 2001·Nature·G I Evan, K H Vousden
Jan 22, 2002·BMC Molecular Biology·S A StephensonJ E Hardingham
Mar 29, 2002·Cancer·Wenbiao LiuLee M Ellis
Jun 20, 2003·Cell Proliferation·Katrien VermeulenDirk R Van Bockstaele
Sep 16, 2003·Nature Cell Biology·Daniel J MarstonCatherine D Nobes
Apr 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nicole K NorenElena B Pasquale
Jun 3, 2005·Cancer Research·Guangbin XiaParkash S Gill
Jun 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Guangbin XiaParkash S Gill

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Citations

Mar 1, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Yanyang TuJianping Deng
Dec 6, 2012·Molecular Pharmaceutics·Dan LiPeter S Conti
Oct 22, 2009·Development, Growth & Differentiation·Stéphanie WeilerAnne-Catherine Andres
Sep 10, 2011·Journal of Oncology·Stéphane Rodriguez, Uyen Huynh-Do
Jun 1, 2013·BMC Cancer·Ren LiuValery Krasnoperov
Feb 12, 2013·Biochimica Et Biophysica Acta·Jessica E LisleSally-Anne Stephenson
Apr 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·M Imran AslamCharles Keller
Mar 13, 2010·Journal of Oncology·Birgit MoschJens Pietzsch
Mar 14, 2012·Journal of Pharmaceutical Sciences·Shuai ShiDavid B Volkin
Dec 14, 2011·International Journal of Cancer. Journal International Du Cancer·Raphael RutkowskiSally-Anne Stephenson
Mar 19, 2016·Birth Defects Research. Part C, Embryo Today : Reviews·Takuya HashimotoAlan Dardik
Feb 6, 2010·The American Journal of Pathology·Valery KrasnoperovParkash S Gill
Jun 26, 2009·The Biochemical Journal·Nicole K NorenElena B Pasquale
Nov 22, 2014·Growth Factors·A C HeringtonS-A Stephenson
Aug 19, 2014·PloS One·Josephine Y FangBo Han
May 17, 2018·Apoptosis : an International Journal on Programmed Cell Death·Mustapha Kandouz
Jun 9, 2016·Molecular and Cellular Biology·Jamie L McCallRobert E Lewis
Aug 18, 2017·PloS One·Matthew E RandolphCharles Keller
Sep 25, 2012·Bioorganicheskaia khimiia·S A Zozulya, I P Udovichenko
Jan 4, 2018·Blood Advances·Akil A MerchantParkash S Gill
Nov 1, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alison MaddiganAndrew Freywald
Oct 15, 2019·Vascular Investigation and Therapy·Jolanta GoreckaAlan Dardik
Jun 26, 2009·Expert Opinion on Therapeutic Patents·Zenghui XuQijun Qian
Jun 1, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shilpa BhatiaSana D Karam
Nov 5, 2010·Molecular Cancer Research : MCR·Mélanie HéroultHellmut G Augustin
Jul 23, 2020·Biology Open·Grace X LiParkash S Gill
Jan 26, 2018·Biochimica Et Biophysica Acta. Reviews on Cancer·Ravi SalgiaPrakash S Gill
Oct 24, 2013·Molecular Pharmaceutics·Dan LiPeter S Conti

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