Epi-Intra neural probes with glassy carbon microelectrodes help elucidate neural coding and stimulus encoding in 3D volume of tissue.

Journal of Neural Engineering
Nasim W VahidiSam Kassegne

Abstract

In this study, we demonstrate practical applications of a novel 3-dimensional neural probe for simultaneous electrophysiological recordings from the surface of the brain as well as deep intra-cortical tissue. We used this 3D probe to investigate signal propagation mechanisms between neuronal cells and their responses to stimuli in a 3D fashion. This novel probe leverage 2D thin-film microfabrication technique to combine an epi-cortical (surface) and an intra-cortical (depth) microelectrode arrays (Epi-Intra), that unfold into an origami 3D-like probe during brain implantation. The flexible epi-cortical component conforms to the brain surface while the intra-cortical array is reinforced with stiffer durimide polymer layer for ease of tissue penetration. The microelectrodes are made of glassy carbon material that is biocompatible and has low electrochemical impedance that is important for high fidelity neuronal recordings. These recordings were performed on the auditory region of anesthetized European starling songbirds during playback of conspecific songs as auditory stimuli. The Epi-Intra probe recorded broadband activity including local field potentials (LFPs) signals as well as single-unit activity and multi-unit activity fro...Continue Reading

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Citations

Apr 30, 2021·Frontiers in Neuroscience·Maryam HejaziDavid J Garrett
Aug 18, 2021·Journal of Neural Engineering·Mamta DeviSwati Sharma

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