Epi-Off versus Epi-On Corneal Collagen Cross-Linking in Keratoconus Patients: A Comparative Study through 2-Year Follow-Up

Journal of Ophthalmology
F CifarielloC Costagliola

Abstract

To evaluate two different techniques of cross-linking: standard epithelium-off (CXL epi-off) versus transepithelial (CXL epi-on) cross-linking in patient with progressive keratoconus. Forty eyes from 32 patients with progressive keratoconus were prospectively enrolled from June 2014 to June 2015 in this nonblinded, randomized comparative study. Twenty eyes were treated by CXL epi-off and 20 by CLX epi-on, randomly assigned, and followed for 2 years. All patients underwent a complete ophthalmologic testing that included uncorrected and best corrected visual acuity, central and peripheral corneal thickness, corneal astigmatism, simulated maximum, minimum, and average keratometry, corneal confocal microscopy, Schirmer I and break-up time (BUT) tests, and the Ocular Surface Disease Index. Intra- and postoperative complications were recorded. The solution used for CXL epi-off comprised riboflavin 0.1% and dextran 20.0% (Ricrolin), whereas the solution for CXL epi-on (Ricrolin TE) comprised riboflavin 0.1%, dextran 15.0%, trometamol (Tris), and ethylenediaminetetraacetic acid. Ultraviolet-A treatment was performed with a UV-X system at 3 mW/cm2. In both groups, a significant improvement in visual function (Group 1: baseline 0.36 ± 0....Continue Reading

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Citations

Jun 6, 2020·European Journal of Ophthalmology·Ahmed ElmassryKarim Gaballah
Dec 20, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Benjamin Laccetti, Julia Kornfield
Mar 26, 2021·The Cochrane Database of Systematic Reviews·Sueko M NgIrene C Kuo
Dec 5, 2020·Experimental Eye Research·Marcella Q SalomãoRenato Ambrósio
Apr 21, 2021·International Ophthalmology·Emre Aydın, Mehmet Gökhan Aslan
Jul 31, 2021·Translational Vision Science & Technology·Brecken J BlackburnWilliam J Dupps
Feb 4, 2021·Asia-Pacific Journal of Ophthalmology·Pauline KhooStephanie L Watson

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Methods Mentioned

BETA
confocal microscopy

Clinical Trials Mentioned

NCT01350323

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