epiCaPture: A Urine DNA Methylation Test for Early Detection of Aggressive Prostate Cancer

JCO Precision Oncology
Eve O'ReillyAntoinette S Perry

Abstract

Liquid biopsies that noninvasively detect molecular correlates of aggressive prostate cancer (PCa) could be used to triage patients, reducing the burdens of unnecessary invasive prostate biopsy and enabling early detection of high-risk disease. DNA hypermethylation is among the earliest and most frequent aberrations in PCa. We investigated the accuracy of a six-gene DNA methylation panel (Epigenetic Cancer of the Prostate Test in Urine [epiCaPture]) at detecting PCa, high-grade (Gleason score greater than or equal to 8) and high-risk (D'Amico and Cancer of the Prostate Risk Assessment] PCa from urine. Prognostic utility of epiCaPture genes was first validated in two independent prostate tissue cohorts. epiCaPture was assessed in a multicenter prospective study of 463 men undergoing prostate biopsy. epiCaPture was performed by quantitative methylation-specific polymerase chain reaction in DNA isolated from prebiopsy urine sediments and evaluated by receiver operating characteristic and decision curves (clinical benefit). The epiCaPture score was developed and validated on a two thirds training set to one third test set. Higher methylation of epiCaPture genes was significantly associated with increasing aggressiveness in PCa tiss...Continue Reading

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Citations

Dec 18, 2019·Clinical Chemistry·Alessandro LealMariana Brait
Nov 13, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Michael J Duffy
Feb 6, 2020·International Journal of Molecular Sciences·João LoboRui Henrique
Jul 13, 2019·Experimental Hematology & Oncology·Igor BrikunDiha Freije
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May 6, 2021·Journal of Clinical Medicine·Óscar Rapado-GonzálezMaría Mercedes Suárez-Cunqueiro
Jul 3, 2021·Journal of Personalized Medicine·Óscar Rapado-GonzálezMaría Mercedes Suárez-Cunqueiro
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Aug 7, 2021·Journal of Personalized Medicine·James MeehanArran K Turnbull
Aug 11, 2021·American Journal of Human Biology : the Official Journal of the Human Biology Council·Alicia M DeLouizeJ Josh Snodgrass

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Methods Mentioned

BETA
biopsy
biopsies
PCR
on

Software Mentioned

Movember
epiCaPture
Amico
GraphPad Prism
R
CAPRA

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