Epicardial adipose tissue: an emerging biomarker of cardiovascular complications in type 2 diabetes?

Therapeutic Advances in Endocrinology and Metabolism
Regitse Højgaard ChristensenPeter Godsk Jørgensen

Abstract

Type 2 diabetes (T2D) is associated with an increased risk of cardiovascular disease and heart failure, which highlights the need for improved understanding of factors contributing to the pathophysiology of these complications as they are the leading cause of mortality in T2D. Patients with T2D have high levels of epicardial adipose tissue (EAT). EAT is known to secrete inflammatory factors, lipid metabolites, and has been proposed to apply mechanical stress on the cardiac muscle that may accelerate atherosclerosis, cardiac remodeling, and heart failure. High levels of EAT in patients with T2D have been associated with atherosclerosis, diastolic dysfunction, and incident cardiovascular events, and this fat depot has been suggested as an important link coupling diabetes, obesity, and cardiovascular disease. Despite this, the predictive potential of EAT in general, and in patients with diabetes, is yet to be established, and, up until now, the clinical relevance of EAT is therefore limited. Should this link be established, importantly, studies show that this fat depot can be modified both by pharmacological and lifestyle interventions. In this review, we first introduce the role of adipose tissue in T2D and present mechanisms inv...Continue Reading

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Citations

Sep 9, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Natja LaunboRegitse H Christensen
Mar 7, 2021·Journal of Clinical Medicine·Caterina Beatrice MontiFrancesco Secchi
Apr 9, 2021·Heart Failure Reviews·Filippos TriposkiadisEfstathios Iliodromitis
Apr 13, 2021·Journal of Cardiovascular Pharmacology and Therapeutics·Emir M MuzurovićDimitri P Mikhailidis
Apr 14, 2021·The Egyptian Heart Journal : (EHJ) : Official Bulletin of the Egyptian Society of Cardiology·Mahfouz El ShahawySukanya Mohan
Jun 27, 2021·Pflügers Archiv : European journal of physiology·Natalia Lucía Rukavina MikusicMarcelo Roberto Choi
Jul 22, 2021·Cardiovascular Diabetology·Hélène BihanEmmanuel Cosson

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Methods Mentioned

BETA
biopsies

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