Epicardial adipose tissue as a predictor of coronary artery disease in asymptomatic subjects

The American Journal of Cardiology
Gil N BacharEli Atar

Abstract

This study sought to elucidate the relation between epicardial adipose tissue (EAT) thickness measured by multidetector computed tomography and presence of coronary artery atherosclerosis. Recent studies have suggested that fat disposition in visceral organs and epicardial tissue could serve as a predictor of coronary artery disease (CAD). The sample included 190 asymptomatic subjects with ≥ 1 cardiovascular risk factor who were referred for cardiac computed tomographic angiography. Body mass index, blood pressure, fasting glucose level, and lipid profile were measured. Multidetector computed tomographic results were analyzed for atherosclerosis burden, calcium Agatston score, and EAT thickness: mean EAT values were 3.54 ± 1.59 mm in patients with atherosclerosis and 1.85 ± 1.28 mm in patients without atherosclerosis (p <0.001). On receiver operating characteristic analysis, an EAT value ≥ 2.4 mm predicted the presence of significant (>50% diameter) coronary artery stenosis. There was a significant difference in EAT values between patients with and without metabolic syndrome (2.58 ± 1.63 vs 2.04 ± 1.46 mm, p <0.05) and between patients with a calcium score >400 and <400 (3.38 ± 1.58 vs 2.02 ± 1.42 mm, p <0.0001). In conclusion,...Continue Reading

References

Mar 15, 1990·Journal of the American College of Cardiology·A S AgatstonR Detrano
Feb 13, 2003·Obesity Research·Gianluca IacobellisFrida Leonetti
Oct 29, 2003·Circulation·Tomasz MazurekYi Shi
Oct 13, 2004·The American Journal of Cardiology·Gianluca IacobellisFrida Leonetti
Sep 27, 2005·Atherosclerosis·Nithima ChaowalitFrancisco Lopez-Jimenez
Mar 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Jin-Won JeongJong Chun Park
Aug 20, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Koji UenoSatoshi Ogawa
Jul 22, 2010·Atherosclerosis·Sandra N Verhagen, Frank L J Visseren
May 18, 2011·Heart Views : the Official Journal of the Gulf Heart Association·Farouk MookadamStephen Cha

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Citations

Sep 13, 2013·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Cristina KarohlPaolo Raggi
May 30, 2014·Diabetology & Metabolic Syndrome·Akif Serhat BalcioğluHaldun Müderrisoğlu
Jun 12, 2013·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Mohammed S AlamBenjamin J W Chow
Aug 28, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Khaled Z Abd-ElmoniemAhmed M Gharib
Nov 18, 2014·Diabetology & Metabolic Syndrome·Gökay NarKorhan Soylu
Oct 31, 2013·The American Journal of Cardiology·Weena J Y ChenPaul Knaapen
Sep 29, 2015·The Journal of Thoracic and Cardiovascular Surgery·Hassiba SmailPierre-Yves Litzler
Sep 6, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Abraam S SolimanCharles A McKenzie
Oct 30, 2013·Clinical and Experimental Dermatology·A BalciE Egilmez
Feb 18, 2014·Atherosclerosis·Nikolaos AlexopoulosPaolo Raggi
Nov 16, 2013·Journal of cardiology·Tadateru IwayamaIsao Kubota
May 7, 2016·International Journal of Obesity Supplements·K Chechi, D Richard
Feb 26, 2015·Forensic Science, Medicine, and Pathology·Damien I SequeiraGaryfalia Ampanozi
Jul 27, 2014·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Hakan TaşolarHasan Pekdemir
Apr 16, 2016·Annals of Dermatology·Emine ColgecenAli Riza Erbay
Mar 13, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hao PengHairong Zheng
Jan 25, 2013·The Open Cardiovascular Medicine Journal·Ioanna PaspalaAnna Tsiligiroglou-Fachantidou
Nov 2, 2019·The European Respiratory Journal·Soriul KimChol Shin
Feb 7, 2020·International Journal of Molecular Sciences·Luis D'MarcoPaolo Raggi
Apr 18, 2013·Current Opinion in Cardiology·Niki KatsikiAnthony S Wierzbicki
Sep 4, 2015·Current Opinion in Nephrology and Hypertension·Mathew P M Graham-BrownJames O Burton
Nov 27, 2020·International Journal of Molecular Sciences·Glória ConceiçãoInês Falcão-Pires

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