Epicardial adipose tissue in patients with end-stage renal disease on haemodialysis

Current Opinion in Nephrology and Hypertension
Mathew P M Graham-BrownJames O Burton

Abstract

Epicardial adipose tissue (EAT) is the visceral fat of the heart, sharing many of the pathophysiological properties of other visceral fat depots. EAT is a metabolically active paracrine and vasocrine organ that causes local cardiac inflammation and is strongly implicated in the pathogenesis of coronary atherosclerosis. This article highlights the findings of recent observational studies in patients on haemodialysis that link the quantity of EAT to increased rates of cardiovascular and coronary artery disease and review the proposed methods of pathogenesis and the possible role of EAT quantification to improve cardiovascular risk assessment. Increasing volumes of EAT in patients on haemodialysis correlate with increased inflammatory mediators, higher rates of cardiovascular disease and coronary artery calcification, independent of general adiposity. EAT is an independent predictor of mortality and a potentially modifiable target for therapeutic interventions. EAT is likely to play a central role in the pathogenesis of cardiovascular disease in patients on haemodialysis, adds incrementally to conventional cardiovascular risk stratification models and is a potential target for therapeutic intervention.

References

Jul 1, 1974·The American Journal of Cardiology·K L Gould, K Lipscomb
Aug 1, 1996·Kidney International·G M LondonF Metivier
Sep 14, 1999·Journal of the American College of Cardiology·T J Anderson
Jun 22, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·P StenvinkelJ Bergström
Jun 22, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A P GuérinF Metivier
Oct 19, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Roberto Pecoits-FilhoPeter Stenvinkel
Mar 13, 2003·Kidney International·Kamyar Kalantar-ZadehJoel D Kopple
May 20, 2003·Kidney International. Supplement·Carmine ZoccaliGiovanni Tripepi
Aug 26, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gérard M LondonHasan Adda
Oct 29, 2003·Circulation·Tomasz MazurekYi Shi
May 19, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Angela Yee-Moon WangJohn E Sanderson
May 30, 2006·Diabetes Care·Isabelle LemieuxPascale Mauriège
Jun 2, 2007·American Heart Journal·Harold S Sacks, John N Fain
Mar 2, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kenneth R WilundBo Fernhall
Jul 16, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Kultigin TurkmenHalil Zeki Tonbul
Jan 21, 2012·The Review of Diabetic Studies : RDS·Maria A Guzzardi, Patricia Iozzo
May 15, 2012·The American Journal of Cardiology·Gil N BacharEli Atar
Sep 25, 2012·Heart Failure Clinics·Peter P Toth
Nov 20, 2012·Atherosclerosis·Mehmet Nuri TuranErcan Ok
Aug 2, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Luis G D'MarcoPaolo Raggi
Sep 13, 2013·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Cristina KarohlPaolo Raggi
Sep 17, 2013·Hemodialysis International·Aydin AtakanCigdem Kaspar
Jan 1, 2014·Echocardiography·Burak AltunFatma Uysal
Jun 1, 2014·Journal of Computer Assisted Tomography·Soeren GauβMohamed Marwan
Jan 30, 2015·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Hülya ÇolakSeyhun Kursat

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Citations

Nov 24, 2016·International Urology and Nephrology·Emad AbdallahOmnia El-Bendary
Mar 6, 2019·Journal of Clinical Medicine·Narothama Reddy AeddulaSamata Pathireddy
Mar 25, 2019·Seminars in Dialysis·Matthew P M Graham-BrownJames O Burton
Feb 18, 2020·World Journal of Diabetes·Zoi KleinakiConstantinos Tsioutis
Jan 2, 2021·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Marta Cano MegíasDiego Rodríguez-Puyol
Jun 26, 2021·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Marta Cano MegíasDiego Rodríguez-Puyol

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Methods Mentioned

BETA
imaging techniques

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