Epicardial adipose tissue, inflammatory biomarkers and COVID-19: Is there a possible relationship?

International Immunopharmacology
Alireza AbrishamiMorteza Sanei-Taheri

Abstract

Adipose tissue is a biologically active organ with pro-immunogenic properties. We aimed to evaluate the prognostic value of epicardial adipose tissue (EAT) in COVID-19 and its correlation with other inflammatory biomarkers. One-hundred patients with COVID-19 were enrolled. C-reactive protein (CRP), lactate dehydrogenase (LDH), neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-CRP ratio (LCR), and platelet-to-lymphocyte ratio (PLR) were evaluated on admission. EAT volume and density were measured by computed tomography. Patients were followed until death or discharge. Univariate and multivariate analysis was performed and ROC curve analysis was used to assess the ability of inflammatory markers in predicting survival. The relationship between EAT and other inflammatory markers was also investigated. The mean ± SD age of patients was 55.5 ± 15.2 years old; 68% were male. Univariate analysis revealed that increased lung involvement, blood urea nitrogen, LDH and NLR, and decreased platelet count were significantly associated with death. After adjustment, LDH was independently predictive of death (OR = 1.013, p-value = 0.03). Among inflammatory markers, LCR had the best ability for predicting survival with 79.7% sensitivity and 64...Continue Reading

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Citations

Feb 7, 2021·Metabolism: Clinical and Experimental·Yuhao ZhaoLei Zhao
Jul 22, 2021·Cardiovascular Diabetology·Hélène BihanEmmanuel Cosson
Jul 7, 2021·International Journal of Clinical Practice·Juan R Ulloque-BadaraccoAdrian V Hernandez

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