Epicardial adipose tissue is associated with extent of pneumonia and adverse outcomes in patients with COVID-19.

Metabolism: Clinical and Experimental
Kajetan GrodeckiDamini Dey

Abstract

We sought to examine the association of epicardial adipose tissue (EAT) quantified on chest computed tomography (CT) with the extent of pneumonia and adverse outcomes in patients with coronavirus disease 2019 (COVID-19). We performed a post-hoc analysis of a prospective international registry comprising 109 consecutive patients (age 64 ± 16 years; 62% male) with laboratory-confirmed COVID-19 and noncontrast chest CT imaging. Using semi-automated software, we quantified the burden (%) of lung abnormalities associated with COVID-19 pneumonia. EAT volume (mL) and attenuation (Hounsfield units) were measured using deep learning software. The primary outcome was clinical deterioration (intensive care unit admission, invasive mechanical ventilation, or vasopressor therapy) or in-hospital death. In multivariable linear regression analysis adjusted for patient comorbidities, the total burden of COVID-19 pneumonia was associated with EAT volume (β = 10.6, p = 0.005) and EAT attenuation (β = 5.2, p = 0.004). EAT volume correlated with serum levels of lactate dehydrogenase (r = 0.361, p = 0.001) and C-reactive protein (r = 0.450, p < 0.001). Clinical deterioration or death occurred in 23 (21.1%) patients at a median of 3 days (IQR 1-13 da...Continue Reading

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Citations

Feb 7, 2021·Metabolism: Clinical and Experimental·Yuhao ZhaoLei Zhao
Apr 7, 2021·Eating and Weight Disorders : EWD·Alexis Elias MalavazosGianluca Iacobellis
Jun 22, 2021·Journal of the American Medical Informatics Association : JAMIA·Yi GuoJiang Bian
Jun 2, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Caterina ContePatrizia Rovere-Querini
Jul 22, 2021·Cardiovascular Diabetology·Hélène BihanEmmanuel Cosson
May 25, 2021·Obesity·Gianluca IacobellisFrancesco Secchi

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Software Mentioned

Slomka
FusionQuant Lung
QFAT
Stata

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