Epicardial adipose tissue volume but not density is an independent predictor for myocardial ischemia

Journal of Cardiovascular Computed Tomography
Michaela M HellDamini Dey

Abstract

Epicardial adipose tissue (EAT) volume is associated with plaque formation and cardiovascular event risk, its density may reflect tissue composition and metabolic activity. Global and regional associations between EAT volume and density, ischemia and coronary calcium were investigated using a novel automatic quantitative measurement software. 71 patients with an intermediate pre-test probability for coronary artery disease and inducible ischemia by SPECT were matched to two same-gender controls (total of 213 patients, 90% male, age 60 ± 10 years). Non-contrast CT for assessment of EAT volume, density (in Hounsfield Unit [HU]) and coronary calcium score (CCS) was performed. Global EAT volume was significantly increased in ischemic patients compared to controls (96 ± 49 vs. 82 ± 36 cm(3), p = 0.04), density showed no significant difference (-75.6 ± 4.3 vs. -75.1 ± 4.1HU, p = 0.63). EAT volume and density differed significantly between coronary territories (LAD: 37 ± 18 cm(3), -77.8 ± 4.5HU; LCx: 16 ± 9 cm(3), -73.9 ± 4.1HU; RCA: 36 ± 17 cm(3), -71.7 ± 4.8HU, p < 0.001). For regional ischemia, only LCx territory showed a significantly higher EAT volume (18 ± 8 vs. 16 ± 9 cm(3), p = 0.048). Multivariable logistic regression reveale...Continue Reading

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Citations

Jun 2, 2018·Heart·Jennifer MancioCharalambos Antoniades
Jul 25, 2019·Frontiers in Physiology·Andrew AntolicMaureen Keller-Wood
Mar 13, 2019·European Radiology·Yasunori NagayamaYasuyuki Yamashita
Nov 20, 2019·Current Atherosclerosis Reports·Andrew LinNitesh Nerlekar
Feb 21, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Wenji YuYuetao Wang
Mar 7, 2021·Journal of Clinical Medicine·Caterina Beatrice MontiFrancesco Secchi
Apr 27, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Masao YamaguchiTsunekazu Kakuta

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