Epicardial Epithelial-to-Mesenchymal Transition in Heart Development and Disease

Journal of Clinical Medicine
Michael KrainockRichard Kim

Abstract

The epicardium is an epithelial monolayer that plays a central role in heart development and the myocardial response to injury. Recent developments in our understanding of epicardial cell biology have revealed this layer to be a dynamic participant in fundamental processes underlying the development of the embryonic ventricles, the coronary vasculature, and the cardiac valves. Likewise, recent data have identified the epicardium as an important contributor to reparative and regenerative processes in the injured myocardium. These essential functions of the epicardium rely on both non-cell autonomous and cell-autonomous mechanisms, with the latter featuring the process of epicardial Epithelial-to-Mesenchymal Transition (EMT). This review will focus on the induction and regulation of epicardial EMT, as it pertains to both cardiogenesis and the response of the myocardium to injury.

References

Jan 1, 1987·Anatomy and Embryology·M KomiyamaY Shimada
Jan 1, 1993·Mechanisms of Development·J F ArmstrongJ B Bard
Dec 19, 2000·Mechanisms of Development·F KrausA Kispert
Apr 9, 2001·Cell and Tissue Research·R CarmonaR Muñoz-Chápuli
Jun 16, 2001·Cells, Tissues, Organs·J MännerR Muñoz-Chápuli
Jun 20, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Daniël G M MolinAdriana C Gittenberger-de-Groot
Dec 31, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·A Wessels, J M Pérez-Pomares
Dec 8, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Timothy F Plageman, Katherine E Yutzey
Nov 1, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Leigh A ComptonJoey V Barnett
Dec 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Esther MerkiPilar Ruiz-Lozano
Feb 4, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Juan A GuadixJosé M Pérez-Pomares
Mar 3, 2006·The Journal of Clinical Investigation·Rannar AirikAndreas Kispert
Oct 27, 2006·Developmental Biology·Elaine L Shelton, Katherine E Yutzey
Nov 1, 2006·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Ismail EralpAdriana C Gittenberger-De Groot
Nov 9, 2007·Proceedings of the National Academy of Sciences of the United States of America·Mónica ZamoraPilar Ruiz-Lozano
Nov 28, 2007·TheScientificWorldJournal·Heleen Lie-VenemaAdriana C Gittenberger-de Groot
Mar 12, 2008·Circulation·Denise P KolditzAdriana C Gittenberger-de Groot
May 16, 2008·Nature·Chen-Leng CaiSylvia M Evans
Aug 23, 2008·Developmental Biology·Somyoth SridurongritVesa Kaartinen
Apr 14, 2009·Journal of Molecular and Cellular Cardiology·Leon EspiraMichael P Czubryt
Apr 17, 2009·Nature·Vincent M ChristoffelsAndreas Kispert
Dec 9, 2009·Journal of Molecular and Cellular Cardiology·Federica LimanaMaurizio C Capogrossi

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Citations

Oct 5, 2017·International Journal of Molecular Sciences·U-Ging LoJer-Tsong Hsieh
Oct 6, 2018·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Rajani M George, Anthony B Firulli
Nov 20, 2018·Journal of Cellular and Molecular Medicine·Shweta SharmaShaik O Rahaman
Jul 28, 2016·Cell and Tissue Research·Rivka C StoneMarjana Tomic-Canic
Jul 9, 2017·Cardiovascular Diabetology·Louis A SaddicJochen D Muehlschlegel
Apr 11, 2019·Journal of Developmental Biology·Emilye HiriartAndy Wessels
Jun 27, 2021·The FEBS Journal·Jiahong XieHongfeng Jiang
Jul 24, 2021·Cell Communication and Signaling : CCS·Jeffrey D Amack

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Methods Mentioned

BETA
genetic knockout
delamination

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