Epicardial Fat Thickness is Increased in Vitamin D Deficient Premenopausal Women and does not Decrease after Short-term Replacement

Journal of Atherosclerosis and Thrombosis
Kadri Murat GursesKudret Aytemir

Abstract

Vitamin D deficiency, which is prevalent among young women in Middle Eastern populations, has been linked to cardiovascular disease. Epicardial adipose tissue (EAT) has also been found to be associated with coronary artery disease. However, data on the relationship between vitamin D status and epicardial adiposity is limited. This study aims to investigate the effect of vitamin D deficiency and replacement therapy on EAT thickness in healthy, young premenopausal women. Thirty-one premenopausal women with vitamin D deficiency and 31 age-matched women with normal vitamin D levels were enrolled in this study. EAT thickness was measured echocardiographically. Measurements were performed at baseline in both groups and were repeated at the 6-month follow-up in vitamin D deficient subjects after vitamin D replacement therapy. The baseline plasma 25-hydroxyvitamin D levels were lower in the vitamin D deficient group compared to the control group and were significantly improved following replacement therapy. EAT thickness was significantly higher in the vitamin D deficient group, and no significant change occurred following replacement therapy. In the linear regression analysis, waist circumference (β=0.031 [0.005-0.057], p=0.020) and 2...Continue Reading

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Citations

Jun 19, 2015·Journal of Atherosclerosis and Thrombosis·Salvatore Chirumbolo
Jun 23, 2015·Journal of Atherosclerosis and Thrombosis·Kadri Murat Gurses, Lale Tokgozoglu
Apr 22, 2015·Journal of Atherosclerosis and Thrombosis·Hirotsugu Yamada, Masataka Sata

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