Epicardial mapping of segmental myocardial function: an echocardiographic method applicable in man

Circulation
M LikoffA Harken

Abstract

A technique for epicardial mapping of segmental myocardial function at multiple sites over both right and left ventricles was developed using a high-resolution, 7.5-MHz, short-focus, miniaturized, M-mode echocardiographic transducer worn on the fingertip. Myocardial function was determined from the extent and time course of systolic thickening and diastolic thinning at each site mapped. The technique was characterized in an open-chest canine model of myocardial ischemia. Ischemia was induced by transient or permanent coronary occlusion in 17 dogs. Acute occlusions produced reduced segmental thickening within 10-15 seconds and, often, overt systolic thinning of ischemic myocardium. Rhodamine fluorescence perfusion maps were compared with echocardiographic maps in nine dogs. Segmental thickening was reduced in perfused segments adjacent to, but not involved by, ischemia, as well as ischemic segments. Reproducibility appeared satisfactory for quantitative analysis of grouped data on multiple segments, and qualitative analysis in individual segments. Initial human studies performed during coronary bypass surgery in 11 subjects showed echocardiographic abnormalities in the six patients with ventriculographic abnormalities and in fou...Continue Reading

Citations

Jan 1, 1987·Cardiovascular and Interventional Radiology·D J Skorton, S M Collins
Feb 1, 1986·Journal of the American College of Cardiology·M E Goldman, B P Mindich
Mar 1, 1987·IEEE Transactions on Bio-medical Engineering·J J McInerneyD S Vanada
Dec 27, 2005·The American Journal of Cardiology·Annemien E van den BoschJolien W Roos-Hesselink
May 28, 2004·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Jürgen FrielingsdorfFrank A Flachskampf
Aug 1, 1986·American Heart Journal·P S DouglasA Harken

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