Epicardial pulmonary vein isolation: a long-term histologic and imaging animal study comparing cryothermy versus radiofrequency

The Annals of Thoracic Surgery
Parwis B RahmanianFarzan Filsoufi

Abstract

Simplifications of the Cox-Maze procedure to treat atrial fibrillation (AF) include epicardial pulmonary vein (PV) isolation using various sources to create lines of conduction block. The creation of transmural lesions has been a concern. The heat-sink effect caused by blood flow has limited the effectiveness of unipolar radiofrequency and linear application of cryothermy, which should be abolished when clamp devices are used for PV isolation. The efficacy and safety of epicardial beating-heart PV isolation with clamp devices using cryothermy or bipolar radiofrequency energy was studied. Twelve domestic pigs underwent beating-heart epicardial PV isolation using cryothermy (n = 6) or radiofrequency (n = 6) energy. Follow-up was 30 days for 3 animals of each group and 90 days for the others. Lesions were assessed by epicardial pacing, cardiac magnetic resonance imaging (MRI), and histologic analysis. Immediate and long-term electrical isolation of PVs was achieved with both energy sources. Histologic analysis showed transmural lesions in all animals at 30 and 90 days. Cardiac MRI showed no evidence of PV stenosis or thrombus formation. Mean left atrial ejection fraction was 0.36 +/- 0.01, 0.36 +/- 0.02, and 0.36 +/- 0.01 at basel...Continue Reading

References

Sep 3, 1998·The New England Journal of Medicine·M HaïssaguerreJ Clémenty
Jul 3, 1999·The Annals of Thoracic Surgery·R LeeJ L Cox
Jul 27, 2001·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·D S LeeD M Newman
Aug 22, 2001·Journal of Cardiovascular Electrophysiology·W C YuS A Chen
May 21, 2004·Journal of Cardiac Surgery·Mathew R WilliamsMichael Argenziano
May 21, 2004·Journal of Cardiac Surgery·João Q MeloAna P Martins
Feb 1, 2005·The Annals of Thoracic Surgery·Taijiro SuedaMasaki Hamamoto
Jan 31, 2007·Stroke; a Journal of Cerebral Circulation·A Marc Gillinov

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Citations

Mar 7, 2009·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Christian von BaryRüdiger Lange
Jun 4, 2013·Journal of Cardiothoracic Surgery·Jean-Marc El AridJean-Christian Roussel

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