Jul 29, 2019

Epicardial therapy with atrial appendage micrografts salvages myocardium after infarction

BioRxiv : the Preprint Server for Biology
Xie YanboAADC Consortium

Abstract

Ischemic heart disease remains the leading cause of mortality and morbidity worldwide despite improved possibilities in medical care. Alongside interventional therapies, such as coronary artery bypass grafting, adjuvant tissue-engineered and cell-based treatments can provide regenerative improvement. Unfortunately, most of these advanced approaches require multiple lengthy and costly preparation stages without delivering significant clinical benefits. We evaluated the effect of epicardially delivered minute pieces of atrial appendage tissue material, defined as atrial appendage micrografts (AAMs), in mouse myocardial infarction model. An extracellular matrix patch was used to cover and fix the AAMs onto the surface of the infarcted heart. The matrix-covered AAMs salvaged the heart from infarction-induced loss of functional myocardium and attenuated scarring. Site-selective proteomics of injured ischemic and uninjured distal myocardium from AAM-treated and untreated tissue sections revealed an increased expression of several cardiac regeneration-associated proteins (i.e. periostin, transglutaminases and glutathione peroxidases) as well as activation of pathways responsible for angio- and cardiogenesis in relation to AAMs therapy...Continue Reading

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Mentioned in this Paper

Extracellular Matrix
Myocardium
Myocardial Infarction
Myocardial Ischemia
Proteomics
Transglutaminases
Glutathione Peroxidase
Dispensing Medication
Heart Tissue
Coronary Artery

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