Epicatechin-3-O-(3″-O-methyl)-gallate content in various tea cultivars (Camellia sinensis L.) and its in vitro inhibitory effect on histamine release

Journal of Agricultural and Food Chemistry
Mari Maeda-YamamotoHirofumi Tachibana

Abstract

It has been reported that epigallocatechin-3-O-(3″-O-methyl)-gallate (EGCG3″Me) and the EGCG3″Me-rich green tea ( Camellia sinensis L.) cultivar 'Benifuuki' exhibit antiallergic effects. The objective of this study was to investigate the effect of various tea leaf catechins on histamine release from murine bone marrow mast cells (BMMC). At a dose of 50 μg/mL, the rank order of histamine release inhibition was observed to be epicatechin-3-O-(3″-O-methyl)-gallate (ECG3″Me) > gallocatechin-3-O-(3″-O-methyl)-gallate (GCG3″Me) > EGCG3″Me > gallocatechin-gallate (GCG) > catechin-gallate (CG) > EGCG > epicatechin-gallate (ECG) > epigallocatechin (EGC) > gallocatechin (GC). Of the various tea cultivars analyzed by HPLC, the greatest content of ECG3″Me was found in the third crop of 'Benifuuki' (1.05% dry weight). Moreover, ECG3″Me content was positively correlated with EGCG3″Me content in 'Benifuuki' tea leaves. In an assay of mixtures of ECG3″Me and EGCG3″Me, inhibitory activity (50 μg/mL in total) was increased as the content of ECG3″Me increased. This suggests that ECG3″Me might link to the antiallergic effect of 'Benifuuki' tea, as has been reported for EGCG3″Me.

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Citations

Sep 15, 2015·Bioscience, Biotechnology, and Biochemistry·Sachiko NomuraHideki Horie
Jul 11, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Fabio Andrés PersiaAlicia Beatriz Penissi
Aug 5, 2016·Journal of Natural Medicines·Yeong-Seon WonHirofumi Tachibana
Jan 16, 2018·Bioscience, Biotechnology, and Biochemistry·Mari Maeda-Yamamoto, Toshio Ohtani
Sep 23, 2016·American Journal of Rhinology & Allergy·Kagan IpciCemal Cingi
Oct 8, 2019·Journal of the Science of Food and Agriculture·Yuan Zhao, Xin Zhang
Feb 2, 2018·Journal of Food and Drug Analysis·Tzu-Yun ChouChia-Chuan Chang
Feb 26, 2020·International Journal of Molecular Sciences·Yuchen GuNathalie Janel
Nov 27, 2020·Food & Function·Qing-Sheng LiJian-Liang Lu
Oct 14, 2017·American Journal of Rhinology & Allergy·Kagan IpciCemal Cingi
Dec 26, 2018·European Journal of Pharmacology·Eriko NakanoShinichi Iwai
Aug 28, 2012·Journal of Agricultural and Food Chemistry·Chen-Chen LeeYu-Ting Lai
Nov 9, 2021·Journal of Food Biochemistry·Akihiro MaetaKyoko Takahashi

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